ID   VP37C_PONAB             Reviewed;         355 AA.
AC   Q5R9T2;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Vacuolar protein sorting-associated protein 37C;
DE   AltName: Full=ESCRT-I complex subunit VPS37C;
GN   Name=VPS37C;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. Required for the sorting of endocytic
CC       ubiquitinated cargos into multivesicular bodies. May be involved in
CC       cell growth and differentiation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I) which consists of TSG101, VPS28, a VPS37
CC       protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry.
CC       Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the
CC       ESCRT-I complex (endosomal sorting complex required for transport I)
CC       which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and
CC       UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2.
CC       Interacts with CEP55 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Note=Probably associates with
CC       membranes. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by TBK1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS37 family. {ECO:0000305}.
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DR   EMBL; CR859300; CAH91478.1; -; mRNA.
DR   RefSeq; NP_001125870.1; NM_001132398.1.
DR   AlphaFoldDB; Q5R9T2; -.
DR   SMR; Q5R9T2; -.
DR   STRING; 9601.ENSPPYP00000003686; -.
DR   GeneID; 100172801; -.
DR   KEGG; pon:100172801; -.
DR   CTD; 55048; -.
DR   eggNOG; KOG3270; Eukaryota.
DR   InParanoid; Q5R9T2; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000813; C:ESCRT I complex; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0036258; P:multivesicular body assembly; IEA:UniProt.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR009851; Mod_r.
DR   Pfam; PF07200; Mod_r; 1.
DR   SUPFAM; SSF140111; SSF140111; 1.
DR   PROSITE; PS51314; VPS37_C; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..355
FT                   /note="Vacuolar protein sorting-associated protein 37C"
FT                   /id="PRO_0000312200"
FT   DOMAIN          78..167
FT                   /note="VPS37 C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00646"
FT   REGION          159..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..209
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..355
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         29
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R105"
SQ   SEQUENCE   355 AA;  38394 MW;  1BF12B70E94C5788 CRC64;
     METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA ERNLEFQGPL
     EISRSNLSDK YQELRKLVER CQEQKAKLEK FSSALQPGTL LDLLQVEGMK IEGESEAMAE
     KFLEGEVPLE TFLENFSSMR MLSHLRRVRV EKLQEVVRKP RASQELAGDA PPPRPPPPVR
     PVPQGTPPVV EEQPQPPSAM PPYPLPYSLS PSLPVGSTAH GALPPAPFPV VSQPSFYSGP
     LGPTYPAAQP GPRGAAGYSW SPQRSTPPRP GYPGTPTGAS GPGYPLAGGR ALSPGYPQQS
     PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP AWPGY