VP37D_MOUSE
ID VP37D_MOUSE Reviewed; 261 AA.
AC Q810I0; Q80UX4; Q8C1V8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Vacuolar protein sorting-associated protein 37D;
DE AltName: Full=ESCRT-I complex subunit VPS37D;
DE AltName: Full=Williams-Beuren syndrome region protein 24 homolog;
GN Name=Vps37d {ECO:0000312|MGI:MGI:2159402};
GN Synonyms=Wbscr24 {ECO:0000312|EMBL:AAL91076.2,
GN ECO:0000312|MGI:MGI:2159402};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL91076.2}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Ucla C., Merla G., Reymond A.;
RT "Novel genes in the Williams-Beuren Syndrome critical region.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC41126.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC41126.1};
RC TISSUE=Brain {ECO:0000312|EMBL:BAC41126.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH44789.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-261 (ISOFORM 1).
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH44789.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I) which consists of TSG101, VPS28, a VPS37
CC protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry.
CC Interacts with TSG101 and MVB12A. Component of the ESCRT-I complex
CC (endosomal sorting complex required for transport I) which consists of
CC TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1
CC stoichiometry (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|Ref.1};
CC IsoId=Q810I0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072, ECO:0000269|Ref.1};
CC IsoId=Q810I0-2; Sequence=VSP_052739;
CC -!- SIMILARITY: Belongs to the VPS37 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH44789.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY081953; AAL91076.2; -; mRNA.
DR EMBL; AY352519; AAQ56179.1; -; mRNA.
DR EMBL; AK090181; BAC41126.1; -; mRNA.
DR EMBL; BC044789; AAH44789.1; ALT_INIT; mRNA.
DR CCDS; CCDS19733.1; -. [Q810I0-2]
DR CCDS; CCDS57388.1; -. [Q810I0-1]
DR RefSeq; NP_001186606.1; NM_001199677.1. [Q810I0-1]
DR RefSeq; NP_808242.1; NM_177574.4. [Q810I0-2]
DR AlphaFoldDB; Q810I0; -.
DR SMR; Q810I0; -.
DR iPTMnet; Q810I0; -.
DR PhosphoSitePlus; Q810I0; -.
DR PaxDb; Q810I0; -.
DR PRIDE; Q810I0; -.
DR ProteomicsDB; 297886; -. [Q810I0-1]
DR ProteomicsDB; 297887; -. [Q810I0-2]
DR Antibodypedia; 48722; 23 antibodies from 11 providers.
DR Ensembl; ENSMUST00000067935; ENSMUSP00000063762; ENSMUSG00000043614. [Q810I0-1]
DR Ensembl; ENSMUST00000076203; ENSMUSP00000075559; ENSMUSG00000043614. [Q810I0-2]
DR GeneID; 194309; -.
DR KEGG; mmu:194309; -.
DR UCSC; uc008zxq.2; mouse. [Q810I0-2]
DR UCSC; uc008zxr.2; mouse. [Q810I0-1]
DR CTD; 155382; -.
DR MGI; MGI:2159402; Vps37d.
DR VEuPathDB; HostDB:ENSMUSG00000043614; -.
DR eggNOG; KOG3270; Eukaryota.
DR GeneTree; ENSGT00950000183012; -.
DR HOGENOM; CLU_081733_0_0_1; -.
DR InParanoid; Q810I0; -.
DR OMA; LQVDREM; -.
DR OrthoDB; 1279157at2759; -.
DR PhylomeDB; Q810I0; -.
DR Reactome; R-MMU-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR BioGRID-ORCS; 194309; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q810I0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q810I0; protein.
DR Bgee; ENSMUSG00000043614; Expressed in ear vesicle and 165 other tissues.
DR Genevisible; Q810I0; MM.
DR GO; GO:0000813; C:ESCRT I complex; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR InterPro; IPR009851; Mod_r.
DR Pfam; PF07200; Mod_r; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endosome; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..261
FT /note="Vacuolar protein sorting-associated protein 37D"
FT /id="PRO_0000328928"
FT DOMAIN 93..182
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00646"
FT REGION 172..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 47..131
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_052739"
SQ SEQUENCE 261 AA; 28563 MW; 1A12D3B0C8A483A4 CRC64;
MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL QLERDACLAS
NYALAKENLA LRPRLEMGRT ALAIKYQELR EVAENCADKL QRLEKSMHRW SPQCALGWLQ
AELEEAEQEA EVQMEQLLLG EQSLEAFLPA FQRGRALAHL RRTQAEKLQE VLRRRERSAQ
PAPTTAAAAA AAATAMDPPK PFPAAAVLPT GAARGPPPAV PRSLPPLDSR PVPPVKGSPG
CPFGPAPLLS PRPSQPEPPH R
