ID   VP3_AHSV4               Reviewed;         905 AA.
AC   P32509; Q64923;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Core protein VP3;
GN   Name=Segment-3; Synonyms=L3;
OS   African horse sickness virus 4 (AHSV-4).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=36421;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Vaccine;
RX   PubMed=1329319; DOI=10.1016/0042-6822(92)90187-t;
RA   Iwata H., Yamagawa M., Roy P.;
RT   "Evolutionary relationships among the gnat-transmitted orbiviruses that
RT   cause African horse sickness, bluetongue, and epizootic hemorrhagic disease
RT   as evidenced by their capsid protein sequences.";
RL   Virology 191:251-261(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Vaccine;
RX   PubMed=8002793; DOI=10.1007/bf01538819;
RA   Sakamoto K., Punyahotra R., Mizukoshi N., Ueda S., Imagawa H., Sugiura T.,
RA   Kamada M., Fukusho A.;
RT   "Rapid detection of African horsesickness virus by the reverse
RT   transcriptase polymerase chain reaction (RT-PCR) using the amplimer for
RT   segment 3 (VP3 gene).";
RL   Arch. Virol. 136:87-97(1994).
CC   -!- FUNCTION: The VP3 protein is one of the five proteins (with VP1, VP4,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP3 family. {ECO:0000305}.
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DR   EMBL; M94681; AAA42538.1; ALT_SEQ; Genomic_RNA.
DR   EMBL; D26572; BAA05621.1; -; Genomic_RNA.
DR   PIR; B44053; P3XRA4.
DR   SMR; P32509; -.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002614; Inner_layer_core_VP3_Orbivir.
DR   InterPro; IPR016029; Inner_layer_core_VP3_Reovir.
DR   Pfam; PF01700; Orbi_VP3; 1.
DR   SUPFAM; SSF56831; SSF56831; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..905
FT                   /note="Core protein VP3"
FT                   /id="PRO_0000222699"
FT   CONFLICT        17..18
FT                   /note="YA -> LS (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="S -> D (in Ref. 1; AAA42538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        121
FT                   /note="I -> V (in Ref. 1; AAA42538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        195
FT                   /note="I -> V (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        231
FT                   /note="Q -> P (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        253
FT                   /note="F -> S (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        403..408
FT                   /note="RALSDY -> AALTII (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        446..456
FT                   /note="DPQTGRGYNGW -> THKRVGLQRV (in Ref. 2; BAA05621)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        560
FT                   /note="F -> L (in Ref. 1; AAA42538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        662
FT                   /note="F -> P (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        708
FT                   /note="Y -> T (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        732
FT                   /note="Y -> H (in Ref. 1; AAA42538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        802..850
FT                   /note="MPYVYTEEERDGVRMVAFKYATTATAYFLLYNVAYSNTPDTLITVNPTF ->
FT                   IANLQANMGQFRAAIRRTLDDNGWIQFGGMLRNIKIKFFDSRPPDEILT (in Ref.
FT                   1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        871
FT                   /note="V -> L (in Ref. 1; AAA42538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        902
FT                   /note="R -> A (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        905
FT                   /note="I -> V (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   905 AA;  103329 MW;  92D8C3C8FAB957A0 CRC64;
     MQGNERIQDK NEKEKAYAPY LDGASVSTDN GPILSVFALQ EIMQKIRQNQ SDMAAHAPDV
     DGAIPEVMTI ISGIKGLLEE KDYKVINAPP NSFRTIPMQS TEYVLQVNTF YERMSEIGGP
     IDETDPIGFY ALILEKLKFL KSEGAFILQG IATKDYRGAE IADPEIIGVS FQNALSHLAA
     IDRQIIQDTL NGMIIENGLV ADRNVDVFRA AMSDPIYRIH NVLQGYIEGI QYGELRESVN
     WLMRLGLRKR IEFANDFLTD FRRADTIWII SQRLPINANV IWNVPRCHIA NLITNVALCL
     PTGEYLMPNP RINSITITQR ITQTNPFSII SGLTPTAVQM NDVRKIYLAL MFPNQIILDI
     KPDSSHAVDP VLRMVAGVLG HVMFTYGPIM TNITPTMAEL LDRALSDYLL YMYNNRIPIN
     YGPTGQPLDF RIGARNQYDC NAFRADPQTG RGYNGWGVVD VQRVQPSPYD HVQRVIRYCD
     IDSREIIDPR TYGMNMTYPI FREMLRMLVA AGKDQEAAYL RQMLPFHMIR FARINQIINE
     DLLSAFSLPD QNFDVVLHNF IQGNFGETDP VVLEVSWASI WFAFVRRFEP IARSDLLEAA
     PLIEARYAAE LSTMQMDVQQ LRMMRARVPD TVINATPSQC WKAVLKNAPE PIKNLMNLSH
     SFSFVNVRDI VRWSQQRDIQ ESLAYVLNRE AWAIANDFED LMLVDHVYIQ RTMLPEPRLD
     DINEFRRQGF FYTNMIDGAP PIGDVTHYTY AIANLQANMG QFRAAIRRTL DDNGWIQFGG
     MLRNIKIKFF DSRPPDEILT AMPYVYTEEE RDGVRMVAFK YATTATAYFL LYNVAYSNTP
     DTLITVNPTF TMTKIHMRKK IVRRVRAPDV VSQVNKRLVA YKGKMRLMDV TKCLKTGVQL
     ARPTI