VP3_BTV1S
ID VP3_BTV1S Reviewed; 901 AA.
AC P56582;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Core protein VP3;
DE AltName: Full=Major inner capsid protein;
GN Name=Segment-3; Synonyms=L3;
OS Bluetongue virus 1 (isolate South Africa) (BTV 1).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=10905;
OH NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
RX PubMed=9774103; DOI=10.1038/26694;
RA Grimes J.M., Burroughs J.N., Gouet P., Diprose J.M., Malby R., Zientara S.,
RA Mertens P.P., Stuart D.I.;
RT "The atomic structure of the bluetongue virus core.";
RL Nature 395:470-478(1998).
CC -!- FUNCTION: The VP3 protein is one of the five proteins (with VP1, VP4,
CC VP6 and VP7) which form the inner capsid of the virus.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP3 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Virus Particle ExploreR db; Note=Icosahedral capsid
CC structure;
CC URL="https://viperdb.scripps.edu/Info_Page.php?VDB=2btv";
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DR PDB; 2BTV; X-ray; 3.50 A; A/B=1-901.
DR PDBsum; 2BTV; -.
DR SMR; P56582; -.
DR DIP; DIP-59519N; -.
DR IntAct; P56582; 2.
DR EvolutionaryTrace; P56582; -.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR002614; Inner_layer_core_VP3_Orbivir.
DR InterPro; IPR016029; Inner_layer_core_VP3_Reovir.
DR Pfam; PF01700; Orbi_VP3; 1.
DR SUPFAM; SSF56831; SSF56831; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Virion.
FT CHAIN 1..901
FT /note="Core protein VP3"
FT /id="PRO_0000222693"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 16..18
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 22..26
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 28..47
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 66..72
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 73..76
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 101..104
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 107..112
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 113..115
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 123..141
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 150..153
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 156..159
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 161..163
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 172..174
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 177..187
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 197..200
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 202..206
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 211..228
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 230..245
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 253..255
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 259..262
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 263..265
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 275..280
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 282..284
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 285..296
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 299..303
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 307..313
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 317..319
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 323..328
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 333..347
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 351..355
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 362..364
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 367..380
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 392..406
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 430..433
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 436..439
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 443..445
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 448..454
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 474..476
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 486..488
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 489..491
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 496..507
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 510..517
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 520..535
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 546..558
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 575..580
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 583..588
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 591..595
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 596..623
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 625..627
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 633..643
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 646..659
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 663..671
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 679..690
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 695..698
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 703..709
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 718..722
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 732..734
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 738..740
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 741..744
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 746..754
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 758..767
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 771..774
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 780..788
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 792..795
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 799..805
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 808..810
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 812..817
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 820..826
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 837..839
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 846..852
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 858..861
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 867..870
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 872..877
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 881..884
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 887..891
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 893..895
FT /evidence="ECO:0007829|PDB:2BTV"
SQ SEQUENCE 901 AA; 103182 MW; B89384F344AE3669 CRC64;
MAAQNEQRPE RIKTTPYLEG DVLSSDSGPL LSVFALQEIM QKVRQVQADY MTATREVDFT
VPDVQQILDD IKALAAAQVY KIVKVPSTSF RHIVTQSRDR VLRVDTYYEE MSQVGDVITE
DEPEKFYSTI IKKVRFIRGK GSFILHDIPA RDHRGMEVAE PEVLGVEFKN VLPVLTAEHR
AMIQNALDGS IIENGNVATR DVDVFIGACS EPFYRIYNRF QGYIEAVQLQ ELRNSIGWLE
RLGQRKRITY SQEVLTDFRR QDMIWVLALQ LPVNPQVVWD VPRSSIANLI MNIATCLPTG
EYIAPNPRIS SITLTQRITT TGPFAILTGS TPTAQQLNDV RKIYLALMFP GQIILDLKID
PGERMDPAVR MVAGVVGHLL FTAGGRFTNL TQNMARQLDI ALNDYLLYMY NTRVQVNYGP
TGEPLDFQIG RNQYDCNVFR ADFATGTGYN GWATIDVEYR DPAPYVHAQR YIRYCGIDSR
ELINPTTYGI GMTYHCYNEM LRMLVAAGKD SEAAYFRSML PFHMVRFARI NQIINEDLHS
VFSLPDDMFN ALLPDLIAGA HQNADPVVLD VSWISLWFAF NRSFEPTHRN EMLEIAPLIE
SVYASELSVM KVDMRHLSLM QRRFPDVLIQ ARPSHFWKAV LNDSPEAVKA VMNLSHSHNF
INIRDMMRWV LLPSLQPSLK LVLEEEAWAA ANDFEDLMLT DQVYMHRDML PEPRLDDIER
FRQEGFYYTN MLEAPPEIDR VVQYTYEIAR LQANMGQFRA ALRRIMDDDD WIGFGGVLRT
VRVKFFDARP PDDILQGLPF SYDTNEKGGL SYATIKYATE TTIFYLIYNV EFSNTPDSLV
LINPTYTMTK VFINKRIVER VRVGQILAVL NRRFVAYKGK MRIMDITQSL KMGTKLAAPT
V
