ID   VP3_BTV2A               Reviewed;         901 AA.
AC   Q65748;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Core protein VP3;
DE   AltName: Full=Major inner capsid protein;
GN   Name=Segment-3; Synonyms=L3;
OS   Bluetongue virus 2 (isolate USA) (BTV 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10907;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8079518; DOI=10.1016/0168-1702(94)90086-8;
RA   Hwang G.-Y., Xiang M., Li J.K.-K.;
RT   "Analyses and conservation of sequences among the cognate L3 segments of
RT   the five United States bluetongue viruses.";
RL   Virus Res. 32:381-389(1994).
CC   -!- FUNCTION: The VP3 protein is one of the five proteins (with VP1, VP4,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP3 family. {ECO:0000305}.
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DR   EMBL; L19967; AAA88825.1; -; Genomic_RNA.
DR   SMR; Q65748; -.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002614; Inner_layer_core_VP3_Orbivir.
DR   InterPro; IPR016029; Inner_layer_core_VP3_Reovir.
DR   Pfam; PF01700; Orbi_VP3; 1.
DR   SUPFAM; SSF56831; SSF56831; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..901
FT                   /note="Core protein VP3"
FT                   /id="PRO_0000222694"
SQ   SEQUENCE   901 AA;  103225 MW;  DA2B7E5E9B252462 CRC64;
     MAAQNEQRPE RIKTTPYLEG DVLSSDSGPL LSVFALQEIM QKVRQVQADY MTATREVDFT
     VPDVQKILDD IKALTVEQVY KIVKVPSISF RHIVMQSRDR VLRVDTYYEE MSQVGDVITE
     DEPEKFYSTI IKKVRFIRGK GSFILHDIPT RDHRGMEAAE PEVLGVEFKN VPPVLTAEHR
     AMIQSALDGS IIENGNVATR DVDVFIGACS EPIYRIYNRL QGYIEAVQLQ ELRNSIGWLE
     RLGQRKRITY SQEVLTDFRR QDTIWVLALQ LPVNPQVVWD VPRSSIANLI MNIATCLPTG
     EYIAPNPRIS SITLTQRITT TGPFAILTGS TPTAQQLNDV RKIYLALMFP GQIILDLKID
     PGERMDPAVR MVAGVVGHLL FTAGGRFTNL TQNMARQLDI ALNDYLLYMY NTRVQVNYGP
     TGEPLDFQIG RNQYDCNVFR ADFATGTGYN GWATIDVEYR DPAPYVHAQR YIRYCGIDSR
     ELINPTTYGI GMTYHCYNEM LRMLVAAGKD SEAAYFRSML PFHMVRFARI NQIINEDLHS
     VFSLPDDMFN ALLPDLVAGA HQNADPVVLD VSWISLWFAF NRSFEPTHRN EMLEIAPLIE
     SVYASELSVM KVDIRHLSLM QRRFPDVLIQ ARPSHFWKAV LNDSPEAVKA VMNLSHSHNF
     INIRDMMRWV LLPSLQPSLK LALEEEAWAA ANDFEDLMLT DQVYMHRDML PEPRLDDIER
     FRQEGFYYTN MLEAPPEIDR VVQYTYEIAR LQADMGQFRA ALRRIMDDDD WVRSDGVLRT
     VRVKFFDARP PDDILQGLPF SYDTNEKGGL SYATIKYATE TTIFYLIYNV EFSNTPDSLV
     LINPTYTMTK VFINKRIVER VRVGQILAVL NRRFVAYKGK MRIMDITQSL KMGTKLAAPT
     V