ID   VP3_CAV26               Reviewed;         120 AA.
AC   P54095;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Apoptin;
GN   Name=VP3;
OS   Chicken anemia virus (isolate USA 26p4) (CAV).
OC   Viruses; Anelloviridae; Gyrovirus.
OX   NCBI_TaxID=73477;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1908516; DOI=10.1099/0022-1317-72-8-2003;
RA   Claessens J.A.J., Schrier C.C., Mockett A.P.A., Jagt E.H.J.M.,
RA   Sondermeijer P.J.A.;
RT   "Molecular cloning and sequence analysis of the genome of chicken anaemia
RT   agent.";
RL   J. Gen. Virol. 72:2003-2006(1991).
CC   -!- FUNCTION: May act as transcriptional regulator. Induces apoptosis in
CC       infected cells. Element of infectious replication cycle.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Host nucleus of infected
CC       cells.
CC   -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC       only after 24 hours.
CC   -!- SIMILARITY: Belongs to the gyrovirus apoptin family. {ECO:0000305}.
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DR   EMBL; D10068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000008442; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019051; P:induction by virus of host apoptotic process; IEA:InterPro.
DR   GO; GO:0039593; P:suppression by virus of host exit from mitosis; IEA:UniProtKB-KW.
DR   InterPro; IPR006858; CAV_VP3.
DR   Pfam; PF04771; CAV_VP3; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Early protein; Host nucleus; Host-virus interaction;
KW   Inhibition of host mitotic exit by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..120
FT                   /note="Apoptin"
FT                   /id="PRO_0000223006"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   120 AA;  13061 MW;  42AB3041581A045E CRC64;
     MNALQEDTPP GPSTVFRPPT SSRPLETPHC EIRIGIAGIT ITLSLCGCAN ARAPTLRSAT
     ADSSESTGFK NAPDLRTDQP KPPSKKRSCD PSEYRVSELK ENLITTTPSR PRTARRCIRL