ID   VP3_CAVCA               Reviewed;         121 AA.
AC   Q9IZU6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Apoptin;
GN   Name=VP3;
OS   Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV).
OC   Viruses; Anelloviridae; Gyrovirus.
OX   NCBI_TaxID=486492;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11022294; DOI=10.1111/j.1751-0813.2000.tb11942.x;
RA   Brown H.K., Browning G.F., Scott P.C., Crabb B.S., Brown K.;
RT   "Full-length infectious clone of a pathogenic Australian isolate of chicken
RT   anaemia virus.";
RL   Aust. Vet. J. 78:637-640(2000).
CC   -!- FUNCTION: May act as transcriptional regulator. Induces apoptosis in
CC       infected cells. Element of infectious replication cycle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Host nucleus of infected
CC       cells. {ECO:0000250}.
CC   -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC       only after 24 hours.
CC   -!- SIMILARITY: Belongs to the gyrovirus apoptin family. {ECO:0000305}.
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DR   EMBL; AF227982; AAF34788.1; -; Genomic_DNA.
DR   Proteomes; UP000007539; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019051; P:induction by virus of host apoptotic process; IEA:InterPro.
DR   GO; GO:0039593; P:suppression by virus of host exit from mitosis; IEA:UniProtKB-KW.
DR   InterPro; IPR006858; CAV_VP3.
DR   Pfam; PF04771; CAV_VP3; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Early protein; Host nucleus; Host-virus interaction;
KW   Inhibition of host mitotic exit by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..121
FT                   /note="Apoptin"
FT                   /id="PRO_0000314475"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   121 AA;  13310 MW;  330B68FD98150DD9 CRC64;
     MNAHQEDTPP GPSTVFRPPT SSRPLETPHC REIRIGIAGI TVTLSLCGCA NARVPTLRSA
     TADNSENTGF KNVPDLRTDQ PKPPSKKRSC DPSEYRVSEL KESLITTTPS RPRTARRCIR
     L