ID   VP3_CAVCI               Reviewed;         121 AA.
AC   P54094;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   02-JUN-2021, entry version 57.
DE   RecName: Full=Apoptin;
GN   Name=VP3;
OS   Chicken anemia virus (isolate USA CIA-1) (CAV).
OC   Viruses; Anelloviridae; Gyrovirus.
OX   NCBI_TaxID=73478;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8971016; DOI=10.1128/jvi.70.12.8872-8878.1996;
RA   Renshaw R.W., Soine C., Weinkle T., O'Connell P.H., Ohashi K., Watson S.,
RA   Lucio B., Harrington S., Schat K.A.;
RT   "A hypervariable region in VP1 of chicken infectious anemia virus mediates
RT   rate of spread and cell tropism in tissue culture.";
RL   J. Virol. 70:8872-8878(1996).
RN   [2]
RP   SEQUENCE REVISION TO 50.
RA   Renshaw R.W.;
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as transcriptional regulator. Induces apoptosis in
CC       infected cells. Element of infectious replication cycle.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Host nucleus of infected
CC       cells.
CC   -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC       only after 24 hours.
CC   -!- SIMILARITY: Belongs to the gyrovirus apoptin family. {ECO:0000305}.
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DR   EMBL; L14767; AAD09423.1; -; Genomic_DNA.
DR   Proteomes; UP000008444; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019051; P:induction by virus of host apoptotic process; IEA:InterPro.
DR   GO; GO:0039593; P:suppression by virus of host exit from mitosis; IEA:UniProtKB-KW.
DR   InterPro; IPR006858; CAV_VP3.
DR   Pfam; PF04771; CAV_VP3; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Early protein; Host nucleus; Host-virus interaction;
KW   Inhibition of host mitotic exit by virus;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..121
FT                   /note="Apoptin"
FT                   /id="PRO_0000223009"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   121 AA;  13245 MW;  D2AAB39C2BD61A3E CRC64;
     MNALQEDTPP GPSTVFRPPT SSRPLETPHC REIRIGIAGI TITLSLCGCA NARAPTLRSA
     TADNSESTGF KNVPDLRTDQ PKPPSKKRSC DPSEYRVSEL KESLITTTPS RPRTARRCIR
     L