ID   VP3_CTFVL               Reviewed;        1182 AA.
AC   Q9ENL3;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Uncharacterized protein VP3;
OS   Colorado tick fever virus (strain USA/Florio N-7180) (CTFV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Coltivirus;
OC   Colorado tick fever coltivirus.
OX   NCBI_TaxID=648168;
OH   NCBI_TaxID=76772; Callospermophilus lateralis (Golden-mantled ground squirrel) (Spermophilus lateralis).
OH   NCBI_TaxID=34620; Dermacentor andersoni (Rocky mountain wood tick).
OH   NCBI_TaxID=34844; Erethizon dorsatum (North American porcupine).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=105147; Neotoma cinerea (Bushy-tailed woodrat).
OH   NCBI_TaxID=10042; Peromyscus maniculatus (North American deer mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10891382; DOI=10.1006/bbrc.2000.3057;
RA   Attoui H., Billoir F., Biagini P., Cantaloube J.F., de Chesse R.,
RA   de Micco P., de Lamballerie X.;
RT   "Sequence determination and analysis of the full-length genome of colorado
RT   tick fever virus, the type species of genus Coltivirus (Family
RT   Reoviridae).";
RL   Biochem. Biophys. Res. Commun. 273:1121-1125(2000).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AF139759; AAG00068.1; -; Genomic_RNA.
DR   RefSeq; NP_690893.1; NC_004183.1.
DR   PRIDE; Q9ENL3; -.
DR   GeneID; 993311; -.
DR   KEGG; vg:993311; -.
DR   Proteomes; UP000001675; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR045917; VP3-like.
DR   Pfam; PF18965; DUF5705; 1.
PE   4: Predicted;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1182
FT                   /note="Uncharacterized protein VP3"
FT                   /id="PRO_0000403191"
FT   TRANSMEM        618..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1182 AA;  135011 MW;  E1F5F3515E9204C9 CRC64;
     MAQLLFRKTT QDFRDCFGLK HEILASIYNE KSTFSSENGS IQILEEAEVN ALGELVRDGT
     VAISFGPGIY SRMFSHLRDD SDYRSALTDC VAHGWKQTRD ARDVREWQRS AAIMCAERYM
     YKVRQAYKRV VENLDHMYAW HYLTEGPSEH VFILPAMYES VRHETTSEAY GMQCGGIIGG
     NVSLMLPRDE QYTTLFKAWL MSLAKMSLSE LREPHWNGVR VQLSRDHRIL YYGDLLPSDG
     DITYLVNKLE YHTIWFPEGD FETMMGAMLR DSFPAGCHAH LNIPVPHYFV FDTDDDLILR
     CWKGVRDTWI KLRLGYEEGG VNDSRMSEAL IVNRDLPADL SESLFCCCLA RGVSRDQVRT
     LKDVRNVAQA QIRHVVSGQG VWWEHMVRGQ PLACSIRPGK VVLVVDYEDG PLHVSIRVRL
     LNVHYARELG MKASDVVVRI PTSNRPRWVE TKEYERSLRF YEFRPGPITT EFHHVFAFYC
     YWGCGRVEKR RHLYQIREVR RGNLYSRSRF LRRIAEDGEK VKVQGRTHVT ATRAVQHEKC
     NPNEDIIYSR EFARELALTG KIKEAGALAV IYTCMQTLGV DIDPPAGWVR EGRPKQRTAK
     LCHLLTRILT AFFSYRGGSS SLVCSVMVVI FSIILYYLRL KHVDQEVRYD ELTLIWYGDG
     GVELQRILRE VSMTRFVAVA GDPATPEYIA QAKLWANKKS NIVVFNYARP YERGPVFENL
     IRDTVSLREA AEVFILRTDD SWSQYGNTVV AMLGEGDFCD LVHFGASCDP MEHYFVHISQ
     PPGTNPGYEP ANQEEPFEEW LYETQAMERV IPTTWESEIV DARGMLVSIL TFHFRFAGWF
     ELDVPGDDIG RGLQLMGSIN KVVHVSCFVQ NGRRYFRLSV DLDVDRVLRN MRHEGDALMA
     AELFVTDAVL VCEGLVVGEM HRLQRTYRSV NAMVYHQGMT NFIVYEWMRR VLLTNLLDEM
     LVFDIGGRNG ELSGWVVQDV KVHYFCVDPA GEEAIPKGQR VRLPGGRAIW DIAETVEQNV
     ARYLEVVGKP QTPAEGIILI FSNSIVAAYE AAGRNNRNQV ANLYQQLQAW GGRVFIRDQL
     VPTRANPGDY WIQAAFPGNV YPPGLCEDFN IDPDAGILPL RYPDTGQGAT DVVLANGRLG
     HLTSSWFQSL YCGAARGFIL NGFGRLIWPI YCRHVVVLAT RP