ID   VP3_EHDV1               Reviewed;         899 AA.
AC   P27281;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   29-SEP-2021, entry version 69.
DE   RecName: Full=Core protein VP3;
GN   Name=Segment-3; Synonyms=L3;
OS   Epizootic hemorrhagic disease virus 1 (EHDV-1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33720;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
OH   NCBI_TaxID=9874; Odocoileus virginianus (White-tailed deer).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1870203; DOI=10.1128/jvi.65.9.4821-4831.1991;
RA   le Blois H., Fayard B., Urakawa T., Roy P.;
RT   "Synthesis and characterization of chimeric particles between epizootic
RT   hemorrhagic disease virus and bluetongue virus: functional domains are
RT   conserved on the VP3 protein.";
RL   J. Virol. 65:4821-4831(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1662848; DOI=10.1016/0168-1702(91)90035-t;
RA   Wilson W.C.;
RT   "Molecular comparison of VP3 from bluetongue and epizootic hemorrhagic
RT   disease viruses.";
RL   Virus Res. 21:225-236(1991).
CC   -!- FUNCTION: The VP3 protein is one of the five proteins (with VP1, VP4,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP3 family. {ECO:0000305}.
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DR   EMBL; M76616; AAA43002.1; -; Genomic_RNA.
DR   EMBL; X61589; CAA43786.1; -; Genomic_RNA.
DR   PIR; A40900; P3XREH.
DR   SMR; P27281; -.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002614; Inner_layer_core_VP3_Orbivir.
DR   InterPro; IPR016029; Inner_layer_core_VP3_Reovir.
DR   Pfam; PF01700; Orbi_VP3; 1.
DR   SUPFAM; SSF56831; SSF56831; 1.
PE   3: Inferred from homology;
KW   Virion.
FT   CHAIN           1..899
FT                   /note="Core protein VP3"
FT                   /id="PRO_0000222701"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        232..233
FT                   /note="RT -> AA (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        299..302
FT                   /note="DMFR -> EYVS (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        749..750
FT                   /note="FE -> LQ (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        768
FT                   /note="R -> G (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        787
FT                   /note="R -> L (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        885
FT                   /note="S -> T (in Ref. 2; CAA43786)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   899 AA;  103496 MW;  7DAA176079312F13 CRC64;
     MADPPDANVP KTSPYLKGDE LSSDSGPLLS IFALQEIMQK VRQAQSEYVA ATKDVDLTVP
     DVQKIIDGVK ELASETIYKI VQKPIISYRH VVMQSRDRFL RVDTYYERMS EVGDKIDENE
     PAKFYETVIK KVRHLRTEGA FILHNIPTKD HRGMEIADPE ILGVDVKSIL PVLTAEHRAM
     IQHVLDGAII ENGNIATRDV DVYLGACSES VYRIYNRLQG YIEAVQLEEL RRTVTWLERL
     GKRKRMTFSQ EFLTDFRRVD TIWVLALRLP ANPRVIWDVP RCSIANLIMN IATCLPTGDM
     FRPNPRIASI TLTQRITTTG PFAILTGSTP TAQQLDDVRK IYLALMFPGQ IILDLKIDPG
     ERMDPAVRMV AGVVGHLMFT AGPRFTNITQ NMARQLDIAL ADFLLYMYNT RIQVQYGPTG
     EPLDFRIGRG QYDCNVFRAN FQTGTGYNGW GLVDVENREP APYDHAQRYI RYCNIDSREL
     IHPATFGIGM NYHCYNEMLR MLVAAGKDTE AAFFRNMLPF HMVRFARINQ VINEDLHSAF
     SMPDDQFNVL LANMVVGQQE RVDPVILDIS WISIWYAFNR SFEPIRRNEM LESAPLIESV
     YASELTVMKT DMQQMALLQR RFPDVLIEAR PTHFWKAVME VSPEPVRAIM DLAHSHSFIN
     IRDMMRWIGL PSMQNSMKLV LEEEAWAVAN DFEELMLTDQ VYMYRDMLPE PRLDDIERFR
     QEGFYYTNML DGPPAIDRVV QYTYEVARFE ANMGQLRAAL RRIMDDERWV RFGGVLRTVR
     IKFFDSRPPE EILQALPFDY QTNEKGGLTY ATIKYANDTT IYYLIYNVEY SNLPDSLVLI
     NPTYVMTKVF MNKRIVERVR VGQALAVMNK RFIAFKGKMR IMDISQALKV GTKLAAPTV