ID   VP3_ORADR               Reviewed;          68 AA.
AC   C7DT09;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Venom peptide 3 {ECO:0000305|PubMed:19857508, ECO:0000312|EMBL:ACU30740.1};
DE            Short=OdVP3 {ECO:0000303|PubMed:19857508};
DE   Flags: Precursor;
GN   Name=VP3 {ECO:0000312|EMBL:ACU30740.1};
OS   Orancistrocerus drewseni (Solitary wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Eumeninae; Orancistrocerus.
OX   NCBI_TaxID=529024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-65.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=19857508; DOI=10.1016/j.toxicon.2009.10.023;
RA   Baek J.H., Lee S.H.;
RT   "Isolation and molecular cloning of venom peptides from Orancistrocerus
RT   drewseni (Hymenoptera: Eumenidae).";
RL   Toxicon 55:711-718(2010).
CC   -!- FUNCTION: Exhibits strong antimicrobial activity against the fungi
CC       C.albicans and B.cinerea, and weaker activity against the Gram-negative
CC       bacterium E.coli and the Gram-positive bacterium S.aureus.
CC       {ECO:0000269|PubMed:19857508}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19857508}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:19857508}.
CC   -!- MASS SPECTROMETRY: Mass=1506.87; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:19857508};
CC   -!- SIMILARITY: Belongs to the MCD family. {ECO:0000255}.
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DR   EMBL; GQ205582; ACU30740.1; -; mRNA.
DR   AlphaFoldDB; C7DT09; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Fungicide; Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..51
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000390689"
FT   PEPTIDE         52..65
FT                   /note="Venom peptide 3"
FT                   /evidence="ECO:0000269|PubMed:19857508"
FT                   /id="PRO_5000502625"
FT   MOD_RES         65
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:19857508"
SQ   SEQUENCE   68 AA;  7111 MW;  A2AF9024BD11178A CRC64;
     MTKQSIVIVL FAAIAMMACL QRVTAEPAPE PIAAPIAEPY ANPEAIASPE AKDLHTVVSA
     ILQALGKK