VP47_NPVAC
ID VP47_NPVAC Reviewed; 401 AA.
AC P34051;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 29-SEP-2021, entry version 73.
DE RecName: Full=DNA-directed RNA polymerase subunit p47;
GN Name=P47;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE, AND SUBCELLULAR LOCATION.
RC STRAIN=HR3;
RX PubMed=8474157; DOI=10.1128/jvi.67.5.2513-2520.1993;
RA Carstens E.B., Lu A.L., Chan H.L.B.;
RT "Sequence, transcriptional mapping, and overexpression of p47, a
RT baculovirus gene regulating late gene expression.";
RL J. Virol. 67:2513-2520(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [3]
RP INTERACTION WITH LEF-4; LEF-8 AND LEF-9, AND FUNCTION.
RX PubMed=9733837; DOI=10.1128/jvi.72.10.7985-7991.1998;
RA Guarino L.A., Xu B., Jin J., Dong W.;
RT "A virus-encoded RNA polymerase purified from baculovirus-infected cells.";
RL J. Virol. 72:7985-7991(1998).
CC -!- FUNCTION: Component of the viral DNA-dependent RNA polymerase which is
CC composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47.
CC Plays an essential role in late and very late gene expression.
CC {ECO:0000269|PubMed:9733837}.
CC -!- SUBUNIT: Interacts with LEF-4, LEF-8, and LEF-9.
CC {ECO:0000269|PubMed:9733837}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:8474157}.
CC -!- SIMILARITY: Belongs to the baculoviridae p47 family. {ECO:0000305}.
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DR EMBL; L07878; AAA16859.1; -; Unassigned_DNA.
DR EMBL; L22858; AAA66670.1; -; Genomic_DNA.
DR PIR; H72854; H72854.
DR RefSeq; NP_054069.1; NC_001623.1.
DR PRIDE; P34051; -.
DR GeneID; 1403872; -.
DR KEGG; vg:1403872; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039695; P:DNA-templated viral transcription; IDA:UniProtKB.
DR GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR InterPro; IPR007799; Baculo_p47.
DR Pfam; PF05112; Baculo_p47; 1.
PE 1: Evidence at protein level;
KW Host nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..401
FT /note="DNA-directed RNA polymerase subunit p47"
FT /id="PRO_0000132908"
FT VARIANT 131
FT /note="V -> M (temperature-sensitive mutant)"
SQ SEQUENCE 401 AA; 47531 MW; 6E1818027042DC3A CRC64;
MFVTRLEHTT QFLPQACKLE DEVLVLYAIY LNGFDYTLPR FVKREVQVNA DGFVRFDYNI
KMFDFARFTD MTQTTPEDID DYINLTRINS LSDHDLKMLQ LVCRDRWYKG DVARLRRILQ
QKDVDDLVKF VCNVMWERAY EDHYTLGQQL SIRITTKLIQ SGLDFKHQPD TTAPVSVRGW
EDATFEKYLQ SITSISEVIK RHVFSKKYIC LEVAASYWSD AVESLQQENF RIILNSKTPY
VLLIEMDDDK NSMVYLRKLA HLLENKIVNL LFVTDVEFYF KNGNFMFYLY NSLKFYYYCL
KNKFAFENVD KEIFFLLYTI VALEWFNGGH LNSFTLEKSA LYNPLELSTR RLNSIKRAAQ
HNRVINCDSE INMDYIRGKR VRTGAHYGKR VVNFDLNQSL H