ID   VP4_AHSV4               Reviewed;         642 AA.
AC   Q64929;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Core protein VP4;
DE   AltName: Full=Inner capsid protein VP4;
GN   Name=Segment-4;
OS   African horse sickness virus 4 (AHSV-4).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=36421;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Vaccine;
RX   PubMed=8346671; DOI=10.1016/0168-1702(93)90029-m;
RA   Mizukoshi N., Sakamoto K., Iwata A., Tsuchiya T., Ueda S., Apiwatnakorn B.,
RA   Kamada M., Fukusho A.;
RT   "The complete nucleotide sequence of African horsesickness virus serotype 4
RT   (vaccine strain) segment 4, which encodes the minor core protein VP4.";
RL   Virus Res. 28:299-306(1993).
CC   -!- FUNCTION: The VP4 protein is one of the five proteins (with VP1, VP3,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP4 family. {ECO:0000305}.
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DR   EMBL; D14402; BAA03305.1; -; Genomic_RNA.
DR   RefSeq; YP_052957.1; NC_006012.1.
DR   SMR; Q64929; -.
DR   GeneID; 2930874; -.
DR   KEGG; vg:2930874; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   CDD; cd20758; capping_2-OMTase_Orbivirus; 1.
DR   Gene3D; 1.20.1280.200; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007753; Orbi_VP4.
DR   InterPro; IPR043026; Orbi_VP4_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF05059; Orbi_VP4; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein; Virion.
FT   CHAIN           1..642
FT                   /note="Core protein VP4"
FT                   /id="PRO_0000222708"
SQ   SEQUENCE   642 AA;  75827 MW;  DF23E2D86D11BD1D CRC64;
     MEPYAILYVT QEIEYLLKDS FLPKWELDGI KDLNTLWLER GRMACDTYAI GKIEQWSVRQ
     LRAHRFLFIS TKRKIRLKDC TISPDIFILK KELKEYDMKR FETLIGRRRV TLRKSFGNML
     RAYAFQHVTV LHGSEAETLS YADPKRHVVK GQPKAAPMYD HPDRWWRDVD DGPTDKKLVS
     MLDYIIYSAD EVYYVGCGDL KTLEQFASRD RKRFDRIKWI CIDPIAPETS YANVKVVREK
     VVSARDLKHY LMRDEVERLL IWDVSADGLK GTIEWEKQRF KEDRNGENIA EALCADFALA
     LIKHRIPEES DEYICRSSWL IPQPGAPITM YELRNLMRLD GYSHVERKHI PRAYARKIDA
     EVARRLVEEY HGEDVGRLLK RSLYEDIHIE RADGLTDGDE RTRADLFYLT NMRNVAFMHD
     VYRVVEKSFI STLWVSNRQN FTYDDVPVNR NFITLRFSKK NRRVLDGNGA ILFLMWQHPK
     DFPKTMNYDP SWAENYAVIF YHALTSPVPD LSLCRFIGLR LMSSTLRINS DRAHQVTDIL
     KKLGLDVSGH LFICLMSNSY VADLDWWFRM ILEWSVKDRE GKLAALSEAK AELIEWRDEK
     ADEPWHIKND LLAALFEFIY FAKHFDINER YVESWIQYLR NA