VP4_BTV10
ID VP4_BTV10 Reviewed; 644 AA.
AC P07132;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Core protein VP4;
GN Name=Segment-4;
OS Bluetongue virus 10 (isolate USA) (BTV 10).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=10900;
OH NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2821504; DOI=10.1093/nar/15.17.7206;
RA Yu Y., Fukusho A., Roy P.;
RT "Nucleotide sequence of the VP4 core protein gene (M4 RNA) of US bluetongue
RT virus serotype 10.";
RL Nucleic Acids Res. 15:7206-7206(1987).
RN [2]
RP SEQUENCE REVISION.
RA Roy P.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The VP4 protein is one of the five proteins (with VP1, VP3,
CC VP6 and VP7) which form the inner capsid of the virus.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP4 family. {ECO:0000305}.
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DR EMBL; Y00421; CAA68483.2; -; mRNA.
DR PIR; A26862; P4XRBV.
DR RefSeq; YP_052969.2; NC_006024.2.
DR PDB; 2JH8; X-ray; 3.22 A; A=1-644.
DR PDB; 2JH9; X-ray; 3.00 A; A=1-644.
DR PDB; 2JHA; X-ray; 3.40 A; A=1-644.
DR PDB; 2JHC; X-ray; 3.00 A; A=1-644.
DR PDB; 2JHP; X-ray; 2.50 A; A=1-644.
DR PDBsum; 2JH8; -.
DR PDBsum; 2JH9; -.
DR PDBsum; 2JHA; -.
DR PDBsum; 2JHC; -.
DR PDBsum; 2JHP; -.
DR SMR; P07132; -.
DR GeneID; 2943157; -.
DR KEGG; vg:2943157; -.
DR EvolutionaryTrace; P07132; -.
DR Proteomes; UP000007662; Genome.
DR GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR CDD; cd20758; capping_2-OMTase_Orbivirus; 1.
DR Gene3D; 1.20.1280.200; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR007753; Orbi_VP4.
DR InterPro; IPR043026; Orbi_VP4_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF05059; Orbi_VP4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; Outer capsid protein; Reference proteome;
KW Virion.
FT CHAIN 1..644
FT /note="Core protein VP4"
FT /id="PRO_0000222705"
FT STRAND 7..10
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 12..14
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 15..18
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 25..27
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 34..41
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 48..52
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 59..64
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 67..77
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 86..88
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 91..95
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 99..112
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 114..128
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 137..141
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 145..147
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 149..152
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 160..162
FT /evidence="ECO:0007829|PDB:2JH9"
FT HELIX 178..186
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 191..196
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 202..210
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 212..216
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 218..223
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 235..238
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 243..245
FT /evidence="ECO:0007829|PDB:2JHA"
FT HELIX 246..249
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 254..256
FT /evidence="ECO:0007829|PDB:2JH9"
FT STRAND 260..264
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 280..295
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 296..299
FT /evidence="ECO:0007829|PDB:2JHA"
FT STRAND 300..308
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 314..324
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 335..341
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 357..362
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 363..373
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 380..391
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 392..394
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 397..399
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 406..408
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 415..417
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 421..430
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 432..437
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 453..460
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 466..469
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 470..480
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 482..484
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 493..496
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 499..503
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 515..517
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 523..533
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 551..561
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 568..576
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 579..581
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 584..586
FT /evidence="ECO:0007829|PDB:2JHP"
FT TURN 587..594
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 612..625
FT /evidence="ECO:0007829|PDB:2JHP"
FT STRAND 627..630
FT /evidence="ECO:0007829|PDB:2JHP"
FT HELIX 635..641
FT /evidence="ECO:0007829|PDB:2JHP"
SQ SEQUENCE 644 AA; 75385 MW; D056FB588006E150 CRC64;
MPEPHAVLYV TNELSHIVKD GFLPIWKLTG DESLNDLWLE NGKYATDVYA YGDVSKWTIR
QLRGHGFIFI STHKNVQLAD IIKTVDVRIP REVARSHDMK AFENEIGRRR IRMRKGFGDA
LRNYAFKMAI EFHGSEAETL NDANPRLHKI YGMPEIPPLY MEYAEIGTRF DDEPTDEKLV
SMLDYIVYSA EEVHYIGCGD LRTLMQFKKR SPGRFRRVLW HVYDPIAPEC SDPNVIVHNI
MVDSKKDILK HMNFLKRVER LFIWDVSSDR SQMNDHEWET TRFAEDRLGE EIAYEMGGAF
SSALIKHRIP NSKDEYHCIS TYLFPQPGAD ADMYELRNFM RLRGYSHVDR HMHPDASVTK
VVSRDVRKMV ELYHGRDRGR FLKKRLFEHL HIVRKNGLLH ESDEPRADLF YLTNRCNMGL
EPSIYEVMKK SVIATAWVGR APLYDYDDFA LPRSTVMLNG SYRDIRILDG NGAILFLMWR
YPDIVKKDLT YDPAWAMNFA VSLKEPIPDP PVPDISLCRF IGLRVESSVL RVRNPTLHET
ADELKRMGLD LSGHLYVTLM SGAYVTDLFW WFKMILDWSA QNREQKLRDL KRSAAEVIEW
KEQMAERPWH VRNDLIAALR EYKRKMGMRE GASIDSWLEL LRHL
