ID   VP4_BTV13               Reviewed;         644 AA.
AC   P33429;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Core protein VP4;
GN   Name=Segment-4;
OS   Bluetongue virus 13 (isolate USA) (BTV 13).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33717;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8393245; DOI=10.1006/viro.1993.1429;
RA   Huang I.J., Hayama E., Jeong Y.J., Li J.K.-K.;
RT   "Conservation of the segment 4 gene sequence and of a leucine zipper motif
RT   in VP4 among five US bluetongue viruses.";
RL   Virology 195:772-779(1993).
CC   -!- FUNCTION: The VP4 protein is one of the five proteins (with VP1, VP3,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP4 family. {ECO:0000305}.
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DR   EMBL; L08640; AAA42827.1; -; mRNA.
DR   SMR; P33429; -.
DR   PRIDE; P33429; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   CDD; cd20758; capping_2-OMTase_Orbivirus; 1.
DR   Gene3D; 1.20.1280.200; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007753; Orbi_VP4.
DR   InterPro; IPR043026; Orbi_VP4_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF05059; Orbi_VP4; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Outer capsid protein; Virion.
FT   CHAIN           1..644
FT                   /note="Core protein VP4"
FT                   /id="PRO_0000222707"
SQ   SEQUENCE   644 AA;  75268 MW;  BA2FEF769BA490E0 CRC64;
     MPEPHAVLYV TNELSHIVKN GFLPIWKLTG DESLNDLWLE NGKYATDVYA YGDVSKWTIR
     QLRGHGFIFI STHKNVQLAD IIKTVDVRIP REVARSHDMK AFENEIGRRR IRMRKGFGDA
     LRNYAFKMAI EFHGSEAETL NDANPRLHKV YGMPEIPPLY MEYAEIGARF DDEPTDEKLV
     SMLDYIVYSA EEVHYVGCGD LRTLMQFKKR SPGRFRRVLW HVYDPIAPEC SDPNVIVHNI
     MVDSKKDILK YMNFLKRVER LFIWDVSSDR SQMNDHEWET TRFAEDRLGE EIAYEMGGAF
     SSALIKHRIP NSKDEYHCIS TYLFPQPGAD ADMYELRNFM RLRGYSHVDR HMHPDASVTK
     VVSRDVRKMV ELYHGRDRGT FLKKRLFEHL HIVRKNGLLH ESDEPRADLF YLTNRCNMGL
     EPSIYEVMKK SVIATAWVGR APLYDYDDFA LPRSTVMLNG SYRDISILDG NGAILYLMWR
     YPDIVKKDLT YDPAWAMNFA VSLKEPIPDP PVPDISLCRF IGLRVESSVL RVRNPTLHET
     ADELKRMGLD LSGHLYVTLM SGAYVTDLFW WFNIILDWSA QNKEQKLRDL KRSAAEVIEW
     KEQMAERPWH VRNDLIRALR EYKRKMGMRE GASIDSWLEL LRHL