ID   VP4_BTV2A               Reviewed;         644 AA.
AC   P33427;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Core protein VP4;
GN   Name=Segment-4;
OS   Bluetongue virus 2 (isolate USA) (BTV 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10907;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8393245; DOI=10.1006/viro.1993.1429;
RA   Huang I.J., Hayama E., Jeong Y.J., Li J.K.-K.;
RT   "Conservation of the segment 4 gene sequence and of a leucine zipper motif
RT   in VP4 among five US bluetongue viruses.";
RL   Virology 195:772-779(1993).
CC   -!- FUNCTION: The VP4 protein is one of the five proteins (with VP1, VP3,
CC       VP6 and VP7) which form the inner capsid of the virus.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP4 family. {ECO:0000305}.
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DR   EMBL; L08637; AAA42824.1; -; mRNA.
DR   SMR; P33427; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   CDD; cd20758; capping_2-OMTase_Orbivirus; 1.
DR   Gene3D; 1.20.1280.200; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007753; Orbi_VP4.
DR   InterPro; IPR043026; Orbi_VP4_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF05059; Orbi_VP4; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Outer capsid protein; Virion.
FT   CHAIN           1..644
FT                   /note="Core protein VP4"
FT                   /id="PRO_0000222704"
SQ   SEQUENCE   644 AA;  75139 MW;  26F2BC9DCED54058 CRC64;
     MPEPHAVLYV TNELSHIVKS GFLPIWRLTG VESLNVLWLE NGKYATDVYA YGDVSKWTIR
     QLRGHGFIFI STHKNIQLAD IIKTVDVRIP REVAKSQDMK AFENEIGRRR IRMRKGFGDA
     LRNKLFKMAI EFHGSEAETL NDANPRLHKI YGMPEMPPLY IEYAEIGTRF DDEPTDEKLV
     SMLDYIVYSA EEVHYVGCGD LRTIMQFKKR SPGRFRRVLW HVYHPIAPES SDPNVIVHNV
     MVDSKKDILK HMNFLKRVER LFIWDVSSDR SQMDDDEWES TRFAEDRLGE EIAYEMGGAF
     SSALIKHRIP NSRDEYHCIS TYLLPQPGAD ADMYELRNFM RLKGYSHVDR HMHPDASVMK
     VVSRDVRKMV ELYHGRDRGR FVKNRLFEHL HIVRKNGLLH ESDEPRADLF YLTNRCNMGL
     EPSIYEVMKK SVIATAWVGR APLYDYDDFA LPRSTVMLNG SYHDIRILDG NGAILFLMWK
     YPDIVKKDLT YDHAWAMNFA VSLKEPIPDP PVPDISLCRF IGLRVESSVL RVRNPTLHET
     ADELKRMGLD LSGHLYVTLM SGAYVTDLFW WFKMILDWSA QSKEQKLRDL KRSAAEVIEW
     KEQMAERPWH VRNSLIAALR EYKRKMGIRE GASIDSWLEL LRHL