ID   VP51_LYCMC              Reviewed;          62 AA.
AC   P0CJ17;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Venom protein 51.1 {ECO:0000312|EMBL:GT028904};
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Neurotoxin. Decreases the action potential of myelinated
CC       nerves in mice and frogs. {ECO:0000250|UniProtKB:P83108}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20663230}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20663230}.
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DR   EMBL; GT028904; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; GT028905; -; NOT_ANNOTATED_CDS; mRNA.
DR   PDB; 6ATY; X-ray; 1.80 A; A=26-62.
DR   PDBsum; 6ATY; -.
DR   AlphaFoldDB; P0CJ17; -.
DR   SMR; P0CJ17; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..62
FT                   /note="Venom protein 51.1"
FT                   /id="PRO_0000403909"
FT   DISULFID        32..53
FT                   /evidence="ECO:0007744|PDB:6ATY"
FT   DISULFID        39..58
FT                   /evidence="ECO:0007744|PDB:6ATY"
FT   DISULFID        43..60
FT                   /evidence="ECO:0007744|PDB:6ATY"
FT   CONFLICT        12..13
FT                   /note="MV -> IF (in Ref. 1; GT028905)"
FT                   /evidence="ECO:0000305"
FT   STRAND          26..31
FT                   /evidence="ECO:0007829|PDB:6ATY"
FT   HELIX           34..36
FT                   /evidence="ECO:0007829|PDB:6ATY"
FT   HELIX           39..45
FT                   /evidence="ECO:0007829|PDB:6ATY"
FT   STRAND          49..54
FT                   /evidence="ECO:0007829|PDB:6ATY"
FT   STRAND          57..61
FT                   /evidence="ECO:0007829|PDB:6ATY"
SQ   SEQUENCE   62 AA;  6804 MW;  D221A214BDEDFB08 CRC64;
     MKFFGILLIV TMVVLVMIAT TYVESISIGI KCSPSIDLCE GQCRIRKYFT GYCSGDTCHC
     SG