ID   VP52B_ARATH             Reviewed;         701 AA.
AC   Q9FVV6; F4I8H2; Q68EC5;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Vacuolar protein sorting-associated protein 52 B;
DE   AltName: Full=ARE1-like protein P2;
GN   Name=P2; OrderedLocusNames=At1g71300; ORFNames=F3I17.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RX   PubMed=15235115; DOI=10.1104/pp.103.037747;
RA   Lobstein E., Guyon A., Ferault M., Twell D., Pelletier G., Bonhomme S.;
RT   "The putative Arabidopsis homolog of yeast vps52p is required for pollen
RT   tube elongation, localizes to Golgi, and might be involved in vesicle
RT   trafficking.";
RL   Plant Physiol. 135:1480-1490(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: May be involved in retrograde transport of early and late
CC       endosomes to the late Golgi. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in pollen. {ECO:0000269|PubMed:15235115}.
CC   -!- SIMILARITY: Belongs to the VPS52 family. {ECO:0000305}.
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DR   EMBL; BK000523; DAA01356.1; -; mRNA.
DR   EMBL; AC016162; AAG51887.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM58262.1; -; Genomic_DNA.
DR   PIR; G96737; G96737.
DR   RefSeq; NP_001320711.1; NM_001334495.1.
DR   AlphaFoldDB; Q9FVV6; -.
DR   SMR; Q9FVV6; -.
DR   BioGRID; 28691; 1.
DR   STRING; 3702.AT1G71300.1; -.
DR   PaxDb; Q9FVV6; -.
DR   PRIDE; Q9FVV6; -.
DR   ProteomicsDB; 242667; -.
DR   EnsemblPlants; AT1G71300.2; AT1G71300.2; AT1G71300.
DR   GeneID; 843471; -.
DR   Gramene; AT1G71300.2; AT1G71300.2; AT1G71300.
DR   KEGG; ath:AT1G71300; -.
DR   Araport; AT1G71300; -.
DR   TAIR; locus:2032318; AT1G71300.
DR   eggNOG; KOG1961; Eukaryota.
DR   HOGENOM; CLU_010797_0_1_1; -.
DR   OMA; LWDRISC; -.
DR   OrthoDB; 158568at2759; -.
DR   PhylomeDB; Q9FVV6; -.
DR   PRO; PR:Q9FVV6; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FVV6; baseline and differential.
DR   Genevisible; Q9FVV6; AT.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR007258; Vps52.
DR   PANTHER; PTHR14190; PTHR14190; 1.
DR   Pfam; PF04129; Vps52; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..701
FT                   /note="Vacuolar protein sorting-associated protein 52 B"
FT                   /id="PRO_0000424844"
FT   COILED          23..45
FT                   /evidence="ECO:0000255"
FT   COILED          511..533
FT                   /evidence="ECO:0000255"
FT   CONFLICT        28
FT                   /note="R -> C (in Ref. 1; DAA01356)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        35
FT                   /note="E -> K (in Ref. 1; DAA01356)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        86
FT                   /note="P -> T (in Ref. 1; DAA01356)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        106
FT                   /note="N -> D (in Ref. 1; DAA01356)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   701 AA;  80713 MW;  C9B31CD56B4204AA CRC64;
     MDDFSNLEKH ESELGAFFGD LAFEEDSRSE DISLEGLQQE LEECESDEVV ANILSSGDKL
     REYAKGVENN LRKVELDSVE VAILLPDYIK ESDKLVSLHD QIRDCNCILS QMETLLSGFQ
     EEIGSISSDI KILQENSMDM GLRLKNRRVT ESKLAKFVED FIVPPKMIHV IVDGEVNEEY
     IKTLGILSKK LKFVETDQAV KSSKALKDVE PELEKLRQKA ISKVYDFIVQ KLIALRKPKT
     NIQILQQSVF LKYKYIISFL KEHGKEVFMD VRAAYIDTMN KVLSAHFQSY IQAFEKLQLD
     IATSNDLIGV DTRSTGLFSR SKEPLKNRCA VFALGERIQI IKEIDQPALI PHIAEASSLK
     YPYEVLFRSL HKLLMDTATS EYIFCEDFFG EQSIFYEIFA GPFSVIYEHL DSVLSSCYDA
     IGLLLMIRII HHHQLIMSRR RIPCLDSYLD KVNISLWPRF KTVFDLHIGS LRNANINTIW
     EDDVHPHYIM RRYAEFTASF IHLNVEYGDG QLDINLERLR MAVDSLILKL AKLFPRPKQQ
     MVFLINNYDM TIAVLKEAEP EGGKIQMHFE ELLKSNTSLF AEELLVEHFS DMIKFVKSRA
     NEDSSPNLER SITVAEVEPL VKDFGSRWKT AIELMHKDII TCFSNFLCGM DILIAGMTQL
     LLYYTRLEDC IKKIDGGSAL NRDIVNYQSI MFEIKKYKKT F