ID   CALM_LYTPI              Reviewed;          27 AA.
AC   P05935; Q9NDV6;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 3.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Calmodulin;
DE            Short=CaM;
DE   Flags: Fragment;
OS   Lytechinus pictus (Painted sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7653;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3651394; DOI=10.1021/bi00386a040;
RA   Hardin S.H., Keast M.J., Hardin P.E., Klein W.H.;
RT   "Use of consensus oligonucleotides for detecting and isolating nucleic
RT   acids encoding calcium binding domains of the troponin C superfamily.";
RL   Biochemistry 26:3518-3523(1987).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Hardin S.H., Keast M.J., Hardin P.E., Klein W.H.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calmodulin mediates the control of a large number of enzymes,
CC       ion channels and other proteins by Ca(2+). Among the enzymes to be
CC       stimulated by the calmodulin-Ca(2+) complex are a number of protein
CC       kinases and phosphatases.
CC   -!- SIMILARITY: Belongs to the calmodulin family. {ECO:0000305}.
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DR   EMBL; M16943; AAA29998.1; -; Genomic_DNA.
DR   EMBL; M25633; AAA30012.2; -; Genomic_DNA.
DR   AlphaFoldDB; P05935; -.
DR   SMR; P05935; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF00036; EF-hand_1; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium; Metal-binding; Repeat.
FT   CHAIN           <1..>27
FT                   /note="Calmodulin"
FT                   /id="PRO_0000198257"
FT   DOMAIN          7..>27
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         20
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
FT   BINDING         22
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
FT   BINDING         24
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         27
SQ   SEQUENCE   27 AA;  3206 MW;  674FCD44FA6742F1 CRC64;
     KKMKDTDSEE EIREAFRVFD KDGNGFI