VP5_AHSV4
ID VP5_AHSV4 Reviewed; 505 AA.
AC Q02168; Q64926;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Outer capsid protein VP5;
GN Name=Segment-6; Synonyms=M6;
OS African horse sickness virus 4 (AHSV-4).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=36421;
OH NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RX PubMed=1329319; DOI=10.1016/0042-6822(92)90187-t;
RA Iwata H., Yamagawa M., Roy P.;
RT "Evolutionary relationships among the gnat-transmitted orbiviruses that
RT cause African horse sickness, bluetongue, and epizootic hemorrhagic disease
RT as evidenced by their capsid protein sequences.";
RL Virology 191:251-261(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RA Iwata H., Yamagawa M., Roy P.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RX PubMed=8075221; DOI=10.1292/jvms.56.321;
RA Sakamoto K., Mizukoshi N., Apiwatnakorn B., Iwata A., Tsuchiya T., Ueda S.,
RA Imagawa H., Sugiura T., Kamada M., Fukusho A.;
RT "The complete sequences of African horsesickness virus serotype 4 (vaccine
RT strain) RNA segment 2 and 6 which encode outer capsid protein.";
RL J. Vet. Med. Sci. 56:321-327(1994).
CC -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC constitute the virus particle outer capsid. Acts as a membrane
CC permeabilization protein that mediates release of viral particles from
CC endosomal compartments into the cytoplasm. Permeabilization activity is
CC probably negatively regulated by VP2 and is triggered by endosomal
CC degradation of VP2 and exposure to low pH (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M94682; AAA42539.1; -; Genomic_RNA.
DR EMBL; M94731; AAA92778.1; -; Genomic_RNA.
DR EMBL; D26571; BAA05620.1; -; Genomic_RNA.
DR PIR; A44053; P5XRA4.
DR RefSeq; YP_052963.1; NC_006018.1.
DR SMR; Q02168; -.
DR GeneID; 2930878; -.
DR KEGG; vg:2930878; -.
DR GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000145; Capsid_VP5_Orbivir.
DR Pfam; PF00901; Orbi_VP5; 1.
PE 3: Inferred from homology;
KW Capsid protein; Outer capsid protein;
KW Viral penetration into host cytoplasm;
KW Viral penetration via permeabilization of host membrane; Virion;
KW Virus entry into host cell.
FT CHAIN 1..505
FT /note="Outer capsid protein VP5"
FT /id="PRO_0000222716"
FT REGION 1..42
FT /note="Involved in membrane permeabilization"
FT /evidence="ECO:0000250"
FT CONFLICT 13
FT /note="N -> S (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
FT CONFLICT 17
FT /note="R -> K (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="Y -> H (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="A -> P (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
FT CONFLICT 444
FT /note="R -> K (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
FT CONFLICT 501
FT /note="G -> R (in Ref. 2; BAA05620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 505 AA; 56780 MW; DA2930C3E899D317 CRC64;
MGKFTSFLKR AGNATKRALT SDSAKKMYKL AGKTLQRVVE SEVGSAAIDG VMQGAIQSII
QGENLGDSIK QAVILNVAGT LESAPDPLSP GEQLLYNKVS EIEKMEKEDR VIETHNAKIE
EKFGKDLLAI RKIVKGEVDA EKLEGNEIKY VEKALSGLLE IGKDQSERIT KLYRALQTEE
DLRTRDETRM INEYREKFDA LKEAIEIEQQ ATHDEAIQEM LDLSAEVIET ASEEVPIFGA
GAANVIATTR AIQGGLKLKE IVDKLTGIDL SHLKVADIHP HIIEKAMLRD TVTDKDLAMA
IKSKVDVIDE MNVETQHVID AVLPIVKQEY EKHDNKYHVR IPGALKIHSE HTPKIHIYTT
PWDSDSVFMC RAIAPHHQQR SFFIGFDLEI EYVHFEDTSV EGHILHGGAI TVEGRGFRQA
YTEFMNAAWG MPTTPELHKR KLQRSMGTHP IYMGSMDYAI SYEQLVSNAM RLVYDSELQM
HCLRGPLKFQ RRTLMNALLY GVKIA