ID   VP5_AHSV6               Reviewed;         504 AA.
AC   O71026;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6; Synonyms=M6;
OS   African horse sickness virus 6 (AHSV-6).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=86060;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9617769; DOI=10.1016/s0168-1702(97)00131-7;
RA   Williams C.F., Inoue T., Lucus A.-M., Zanotto P., Roy P.;
RT   "The complete sequence of four major structural proteins of African horse
RT   sickness virus serotype 6: evolutionary relationships within and between
RT   the orbiviruses.";
RL   Virus Res. 53:53-73(1998).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; AF021237; AAC40996.1; -; mRNA.
DR   SMR; O71026; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..504
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222717"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   504 AA;  56901 MW;  6962AE8060A1A672 CRC64;
     MGKFTSFLKR AGSATKNALT SDAAKRMYKM AGKTLQKVVE SEVGSSAIDG VMQGTIQSII
     QGENLGDSIR QAVILNVAGT LESAPDPLSP GEQLLYNKVS EIERAEKEDR VIETHNKKII
     EKYGEDLLEI RKIMKGEAEA EQLEGKEMEY VEKALKGMLK IGKDQSERIT RLYRALQTEE
     DLRTSDETRM ISEYREKFDA LKQAIELEQQ ATHEEAMQEM LDLSAEVIET AAEEVPIFGA
     GQANVVATTR AIQGGLKLKE IIDKLTGIDL SHLKVADIHP HIIEKAMLKD RIPDNELAMA
     IKSKVEVIDE MNTETEHVIE SIIPLVKKEY EKHDNKYHVN IPSALKIHSE HTPKVHIYTT
     PWDSDKVFIC RCIAPHHQQR SFMIGFDLEV EFVFYEDTSV EGHIMHGGAV SIEGRGFRQA
     YSEFMNSLVY PSTPELHKRR LQRSLGSHPI YMGSMVITVS YEQLVSNAMK LVYDTDLQMH
     CLRGPLKFQR RTLMNALLFG VKVA