ID   VP5_AHSV9               Reviewed;         505 AA.
AC   Q96597;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6; Synonyms=M6;
OS   African horse sickness virus 9 (AHSV-9).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10897;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9037735; DOI=10.1016/s0168-1702(96)01400-1;
RA   du Plessis M., Nel L.H.;
RT   "Comparative sequence analysis and expression of the M6 gene, encoding the
RT   outer capsid protein VP5, of African horsesickness virus serotype nine.";
RL   Virus Res. 47:41-49(1997).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U74489; AAB17570.1; -; Genomic_RNA.
DR   SMR; Q96597; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..505
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222718"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   505 AA;  56771 MW;  4E55590F4D45DD3D CRC64;
     MGKFTSFLKR AGSATKKALT SDAAKRMYKM AGKTLQKVVE SEVGSAAIDG VMQGTIQSII
     QGENLGAQFK QAVILNVAGT LESAPDPLNP GEQHIIINVS EIERAEKEDR VIETHNKKII
     ERFGGHLLKI RKIMKGEAEA EQLEGKEMMQ VEKALKGMLR IGKDQSERIT RLYRALQTEE
     DLRTSDETRM ISEYREKFEA LKQAIELEQQ ATHGEAVQEM LDLSAEVIET AAEEVPVFGA
     GRANVVATTR AIQGGLKLKE IIDKLTGIDL SHLKVADIHP HIIEKAMQSD KIPDNRLAMA
     IKSKVEVIDE MNTETEHVYD PSCLIVKKEY EKHDNKYHVN IPSALKIHSE HTPKVHIYTT
     PWDSDKVFIC RCIAPHHQQR SFMIGFDLEI EFVFYEDTSV EGHIKHGGAV SIEGRGFRQA
     YSEFMNAAWS MPSTPELHKE KMQRSLGSHP IYMGSMDYTV SYEQLVSNEM KLVYDTDLQM
     HCLRGPLKIP KGTLMNALLF AVKVA