ID   VP5_AQRVC               Reviewed;         728 AA.
AC   Q8JU58;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 39.
DE   RecName: Full=Microtubule-associated protein VP5;
GN   Name=S5;
OS   Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Aquareovirus.
OX   NCBI_TaxID=185783;
OH   NCBI_TaxID=28800; Notemigonus crysoleucas (Golden shiner) (Cyprinus crysoleucas).
OH   NCBI_TaxID=90988; Pimephales promelas (Fathead minnow).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12124458; DOI=10.1099/0022-1317-83-8-1941;
RA   Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P.,
RA   de Micco P., de Lamballerie X.;
RT   "Common evolutionary origin of aquareoviruses and orthoreoviruses revealed
RT   by genome characterization of Golden shiner reovirus, Grass carp reovirus,
RT   Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family
RT   Reoviridae).";
RL   J. Gen. Virol. 83:1941-1951(2002).
CC   -!- FUNCTION: Minor inner capsid component. Displays NTPase and RNA 5'-
CC       triphosphatase (RTPase) activities. May function as a cofactor of
CC       polymerase. Associates with microtubules and plays a role in the
CC       formation, structural organization and morphology of viral inclusions,
CC       where the assembly of cores and the replication of viral RNA occur (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm, host
CC       cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the reoviridae microtubule-associated protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF403402; AAM92748.1; -; Genomic_RNA.
DR   RefSeq; NP_938064.1; NC_005170.1.
DR   SMR; Q8JU58; -.
DR   GeneID; 2648333; -.
DR   KEGG; vg:2648333; -.
DR   Proteomes; UP000006713; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR012494; Reovirus_Mu2.
DR   Pfam; PF07781; Reovirus_Mu2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cytoplasm; Host cytoskeleton; Outer capsid protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..728
FT                   /note="Microtubule-associated protein VP5"
FT                   /id="PRO_0000404189"
SQ   SEQUENCE   728 AA;  80247 MW;  A587AA7D650520E2 CRC64;
     MITIVVIPTA HFSWTDTNFL NSVDYRLTSQ PKIRDRFAVY APGWLRRQLD EFSASLTASE
     LLQALQTIPI PVKARCLLLP KPKRFAQWLL DVPSANIWHI PVTTLRATVA SKHPSSDVYN
     YIPDHVPPSA EFDTVTRRVA AGRDIYVRST KVLGAPLCLA APAKYYAGYL STHQLDGVYP
     DNWAPDNFHK REFCLTILPS LLGPRTFLLD VDADRDASYP LSVLWPQLRV LALKSRLLLP
     PVALLRRVVD PGLKPTWSAD SDAAFRALRL SRPSSASKPT GFDFSALPVV DIICLFESEP
     DDHGRVAPGT RLTIHSVPTD LLTSLSIQEG VRYPLRQESG MFVPWVLLAL LMSDDVTISG
     TRRSVKLETA HASARPFVHI TVERCASARV VDVRGSPAMY ANAVCLTLPK GSYKSTIIDT
     LPAMFSDLSI LEQAAVIDSD ALGDSLRPSF ETQFLERLEN LDPKLLDRAV ASILSPASDT
     SDDAVTTVLD VFNALYREVM TPAQRSRLPL LTQQGRVLAF AHSDYELLSA NIPIQVVRGS
     IPIDHVVNLL ARRNRVGGTA LQVLLDYCYR TQASPLAPTP AGRLYKQLFG PWLMVPRLSD
     PLIKLRLVAS APAKVLRAAG WTIDGDPPLE VSCLCAYVTD RAMAAALIER RLDSRALVNV
     GGDQLMFVEY APPLPLVSIP RTFLLPVTYV VHWVSPQRVL LNGGNVSFTS GLEWTFDDDP
     QVVTSTGV