ID   VP5_AQRVG               Reviewed;         728 AA.
AC   B2BNE3;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   23-FEB-2022, entry version 34.
DE   RecName: Full=Microtubule-associated protein VP5;
GN   Name=S5;
OS   Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Aquareovirus.
OX   NCBI_TaxID=648234;
OH   NCBI_TaxID=7959; Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18191982; DOI=10.1016/j.virol.2007.12.006;
RA   Mohd Jaafar F., Goodwin A.E., Belhouchet M., Merry G., Fang Q.,
RA   Cantaloube J.F., Biagini P., de Micco P., Mertens P.P., Attoui H.;
RT   "Complete characterisation of the American grass carp reovirus genome
RT   (genus Aquareovirus: family Reoviridae) reveals an evolutionary link
RT   between aquareoviruses and coltiviruses.";
RL   Virology 373:310-321(2008).
CC   -!- FUNCTION: Minor inner capsid component. Displays NTPase and RNA 5'-
CC       triphosphatase (RTPase) activities. May function as a cofactor of
CC       polymerase. Associates with microtubules and plays a role in the
CC       formation, structural organization and morphology of viral inclusions,
CC       where the assembly of cores and the replication of viral RNA occur (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm, host
CC       cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the reoviridae microtubule-associated protein
CC       family. {ECO:0000305}.
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DR   EMBL; EF589102; ABV01043.1; -; Genomic_RNA.
DR   RefSeq; YP_001837098.1; NC_010588.1.
DR   SMR; B2BNE3; -.
DR   GeneID; 6218803; -.
DR   KEGG; vg:6218803; -.
DR   Proteomes; UP000001674; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR012494; Reovirus_Mu2.
DR   Pfam; PF07781; Reovirus_Mu2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cytoplasm; Host cytoskeleton; Outer capsid protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..728
FT                   /note="Microtubule-associated protein VP5"
FT                   /id="PRO_0000404190"
SQ   SEQUENCE   728 AA;  80134 MW;  CDE0351FF1B89EA5 CRC64;
     MITIVVIPTE RFPWTDTNLL NSIDYRLNNI PKSNQRFAVY APAWLRLQLE EAAVSLTPSQ
     LLAAIQDIHV PVTSTFALLP KAKRFAQWLL DDPSSNIWHI PVTVLNVTAT SKHPTSDIFN
     YVVGHVSPNA ELATTASRVS GTQVVYTRTS KVLGAPLRLA APTSYYSGYL SSQQLSHVYP
     SSWTPETFKK KEICFTILPS LTSPKTFLLD VDAPRDPSFP LSVMWPLLRN DAVKSHRLMP
     PNALLRRTVD PALKPEWSAD VDPSFRALRL SRPRGANTSS CHNRHHVPVC DIQCALTPEP
     LNDSEKPPAT HITIHAVPSD LLTVLDITVG KEYPLRLESG MYVPWMLMSL LMSDDVTLTG
     TRRSVKLETA HAAQRPFTQV KILRCVSARV TSVRAGPATY LNAVCLTLPK GSFKSTMIDT
     LPSLFPEWPV VSTTAIVDSD HLGDSLDPTF EQRFATMLET LPPGTVDQAI RVALATCPTA
     DETALQLIVT SFNELYASCM TEAQRNRVPI LTQQGRTLVF AHSDYEMLAA NVPIQVIRGA
     IPIDHTVNII ARPNRVGGTA LQLLLDYCYR MQASPIATMP AGALYRQLFG PWLRAKADCE
     QLTPVSLIAE VPARVMRAAG WTIQDDMPLI INVMRCYRNV DDQIDDVLTR TETSRAIITI
     SADGIILVEY APPLPLITLP SSILLPATYT ATWLEPPRIL LTGSNVSVTS GLSWAEVGSP
     LDVPPPGV