ID   VP5_BRD                 Reviewed;         480 AA.
AC   P21230;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6;
OS   Broadhaven virus (BRD).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10893;
OH   NCBI_TaxID=6944; Ixodes.
OH   NCBI_TaxID=8910; Laridae (gulls).
OH   NCBI_TaxID=9205; Pelecaniformes (Ibis, herons and pelicans).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2171220; DOI=10.1016/0042-6822(90)90320-q;
RA   Moss S.R., Fukusho A., Nuttall P.A.;
RT   "RNA segment 5 of broadhaven virus, a tick-borne orbivirus, shows sequence
RT   homology with segment 5 of bluetongue virus.";
RL   Virology 179:482-484(1990).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; M58030; AAA42802.1; -; Genomic_RNA.
DR   PIR; A45339; A45339.
DR   SMR; P21230; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..480
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222720"
FT   REGION          1..48
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   480 AA;  52522 MW;  28DFD78B2BE923A1 CRC64;
     MTSKRLGARF PGFLNRIGSG ITRAARSDTT KRIPSAAGRA VERVAASEIG QRAIAGVVEG
     AATAALTGES VGESVKRAVI LNVAGVHQTV PDPLNPVEIE TQAKLRELDL ANKREEAQIR
     HNKSMLQKEA QILGEVQHLM TVQEHVDQAK YEVRSGRALQ AAQAIVKGER QQLDRVTKAL
     IRENEMRTTD ERKLIEGMRH NYSALAKSVD ADSALIEEAV EQTVDIGGEI AEHATASIPF
     VGEAVSAGMA TARGAMQIYR LGKTIHAITG LHTNHCEIPA IHQGAIETLL TSDSPTSDAS
     LAQITSSRVR HLREIESELA HLDAEVKPAM QQMCQDIAKL APDHLKKRRG VIHMNAAHEL
     RVPLKQRPMI HSYTSPWDSD YVLILHVVGP YHSGQAFVFC LDLALDQFHF EEDTGSKPPV
     PPPRHRAPAD FSARPAPISL SPLLAILTQR GCIGPGWPRV LMIRPCISAL YRTRPPTRRC