ID   VP5_BTV13               Reviewed;         526 AA.
AC   P25179;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   12-AUG-2020, entry version 54.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6; Synonyms=M5;
OS   Bluetongue virus 13 (isolate USA) (BTV 13).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33717;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1847179; DOI=10.1099/0022-1317-72-2-449;
RA   Oldfield S., Hirasawa T., Roy P.;
RT   "Sequence conservation of the outer capsid protein, VP5, of bluetongue
RT   virus, a contrasting feature to the outer capsid protein VP2.";
RL   J. Gen. Virol. 72:449-451(1991).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; X54308; CAA38205.1; -; Genomic_RNA.
DR   PIR; A38481; P5XRBT.
DR   SMR; P25179; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..526
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222714"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  59195 MW;  0FFA0CE207FFA173 CRC64;
     MGKIIKSLSR FGKKVGNALT SNTAKKIYNT IGKAAERFAE SEIGSAAIDG LVQGSVHSII
     TGESYGESVK QAVLLNVLGA GDEIPDPLSP GERGIQTKIK EIEEEQRNEL VRIKYGKEIR
     EKFGEQLEEI YQFMNGEVKG EEEQEEQYKV LCKAVDSYEN LLVTENEQMR TLARALQREA
     TERTENESKM VKEYRQKIDA LKVAIEVERD GMQEEAIQEI AGMTADVLEA ASEEVPLVGS
     GMATAIATGR AIEGAYKLKK VINALSGIDL SHLRTPKIEP TMVATTLEHR FKEIPDKELA
     VSVLAKNDAI VANTKEIKHI KEEILPKFKK IMEEEKELEG IDDKKIHPRV MMRFKVPRSQ
     QPQIHIYSAP WDSDDVFFFH CVSHFHANES FFLGFDLGID VVHFEDLAAH WHALGAAQEA
     KGRTLNEAYR EFLNLSIGSA FTSPMHARRM IRSKTVHPIY LGSMHYDITY ETLKTNATEA
     RYDEDLQMHI LRGPLHFQRR AILGALKFGV KVLGDKVDVP LFLKNA