ID   VP5_BTV17               Reviewed;         526 AA.
AC   P69364; P33430; P33476;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   12-AUG-2020, entry version 38.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6; Synonyms=M3;
OS   Bluetongue virus 17 (isolate USA) (BTV 17).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33718;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1318625; DOI=10.1016/0168-1702(92)90075-k;
RA   Yang Y.-Y., Li J.K.-K.;
RT   "Complete genomic sequences of the GP5 protein gene of bluetongue virus
RT   serotype 11 and 17.";
RL   Virus Res. 23:163-171(1992).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; X55359; CAA39043.1; -; Genomic_RNA.
DR   SMR; P69364; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..526
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222715"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  59279 MW;  928B53D4E46F2B6D CRC64;
     MGKIIKSLSR FGKKVGNALT SNTAKKIYST IGKAAERFAE SEIGAATIDG LVQGSVHSII
     TGESYGESVK QAVLLNVLGT GEELPDPLSP GERGIQTKIK ELEDEQRNEL VRLKYNKEIT
     KEFGKELEEV YDFMNGEAKE EEVVQEQYSM LCKAVDSYEK ILKAEDSKMA MLARALQREA
     SERSQDEIKM VKEYRQKIDA LKNAIEIERD GMQEEAIQEI AGMTADVLEA ASEEVPLIGA
     GMATAVATGR AIEGAYKLKK VINALSGIDL SHMRSPKIEP TIIATTLEHR FKEIPDEQLA
     VSVLNKKTAV TDNCNEIAHI KQEILPKFKQ IMDEEKEIEG IEDKVIHPRV MMRFKIPRTQ
     QPQIHIYAAP WDSDDVFFFH CVSHHHRNES FFLGFDLGID VVHFEDLTSH WHALGLAQEA
     SGRTLTEAYR EFLNLSISST YSSAIHARRM IRSRAVHPIF LGSMHYDITY EALKNNAQRI
     VYDEELQMHI LRGPLHFQRR AILGALKFGV KILGDKIDVP LFLRNA