ID   VP5_BTV1A               Reviewed;         526 AA.
AC   P12436;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6;
OS   Bluetongue virus 1 (isolate Australia) (BTV 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10904;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2837015; DOI=10.1016/0168-1702(88)90088-3;
RA   Gould A.R., Pritchard L.I.;
RT   "The complete nucleotide sequence of the outer coat protein, VP5, of the
RT   Australian bluetongue virus (BTV) serotype 1 reveals conserved and non-
RT   conserved sequences.";
RL   Virus Res. 9:285-292(1988).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; M21845; AAA42849.1; -; Genomic_RNA.
DR   PIR; JS0323; P5XR15.
DR   SMR; P12436; -.
DR   PRIDE; P12436; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..526
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222709"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  59244 MW;  4A10FE249404B120 CRC64;
     MGKVIRSLSR FGKKVGNALT SNTAKKIYST IGKAAERFAE SEIGSAAIDG LVQGSVHSIL
     TGESYGEYVK QAVLLNVLGS GEEIPDPLSQ GETEIQAKLR ELEDEQRNEL VRLKYNDKIK
     EKFGEELEEV YEFMNGAAKA EVEDEKQFDI LNKAVTSYNK ILTEEDLQMR RLANALQKEI
     GERTHAETVM VKEYRNKIDA LKNAIEIERD GMQEEAIQEI AGMTRGVLEA ASEEVPLIGA
     GMATAVATGR AIEGAYKLKK VINALSGIDL THLRTPKIEP SVVSTILEYR TRAIPDSALA
     VSVLSKNRAI QENHKELIHI KDEILPRFKK AMDEEKEICG IEDKTIHPKV MMRFKIPRAQ
     QPQIHVYSAP WDSDDVFFFH CISHHHANES FFLGFDLSID LVHYEDLTAH WHALGAAQMA
     MGRTLSEAYK EFLNMAISNA YGTQMHTRRL VRSKMVHPIY LGSLHYDISF LDLRGNAQRI
     VYDDELQMHI LRGPIHFQRR AILGALKFGC KVLGDRLDVP LFLRNA