ID   VP5_BTV1S               Reviewed;         526 AA.
AC   P33475;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   23-FEB-2022, entry version 55.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6; Synonyms=S5;
OS   Bluetongue virus 1 (isolate South Africa) (BTV 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10905;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2848383; DOI=10.1016/0168-1702(88)90085-8;
RA   Wade-Evans A.M., Pan Z.Q., Mertens P.P.C.;
RT   "Sequence analysis and in vitro expression of a cDNA clone of genome
RT   segment 5 from bluetongue virus, serotype 1 from South Africa.";
RL   Virus Res. 11:227-240(1988).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; M36713; AAA42848.1; -; Genomic_RNA.
DR   PIR; A45185; A45185.
DR   SMR; P33475; -.
DR   DIP; DIP-59520N; -.
DR   IntAct; P33475; 1.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..526
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222710"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  59422 MW;  2017A4A2CDF4FEE8 CRC64;
     MGKVIRSLNR FGKKVGNALT SNTAKKIYST IGKAADEFLE SEIGSAAIDG LVQGSVHSII
     TGESYGESVK QAVLLNVLGS GEEIPDPLSP GERGIQAKLK ELEDEQRNEL VRLKYNDKIK
     EKFEKELEEV YNFYNGEANA EIEDEKQFDI LNKAVTSYNK ILTEEDLQNR RLATRLQKEI
     GERTHAETVM VKEYRDKIDA LKNAIEVERD GMQEEAIQEI AGMTADVLEA ASEEVPLIGA
     GMATAVATGR AIEGAYKLKK VINALSGIDL THFTHYENRP SVVSTILEYR AKEIPDNALA
     VSVLIKERAI QENHKELMHI KNEILPRFKK AMDEEKEIMR DRRQMIHPKV MMKFKIPRAQ
     QPQIHVYSAP WDSDDVFFFH CISHHHANDS FFLGFDLSID LVHYEDLTAH AHAIGAAQTA
     AGRTLTEAYR EFLNLAISKA FGTQMHTRRL VRSKTVHPIY LGSLHYDISF SDLRGNAQRI
     VYDDELQMHI LRGPIHFQRR AILGALKFGC KVLGDRLDVP LFLRNA