ID   VP5_BTV2A               Reviewed;         526 AA.
AC   P30209;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6;
OS   Bluetongue virus 2 (isolate USA) (BTV 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10907;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2157314; DOI=10.1016/0168-1702(90)90002-s;
RA   Hirasawa T., Roy P.;
RT   "The complete nucleotide sequence of VP5 of a strain of bluetongue virus of
RT   serotype 2 isolated in the USA reveals its close relationship with a virus
RT   of serotype 1 isolated in Australia.";
RL   Virus Res. 15:107-112(1990).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; X62283; CAA44172.1; -; Genomic_RNA.
DR   PIR; A43486; P5XRBU.
DR   SMR; P30209; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..526
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222711"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  58954 MW;  DE50D6013B983A04 CRC64;
     MGKVIRSLSR FGKKVGSALT SNAAKKIYST IGKAAERFAE SEIGSAATDG LVQGSVHSIL
     TGESYGESVK QAVLLNVLGS GEEIPDPLSP GEQGMQTKLK ELEEEQRNEL VRLKYNDKIK
     EKFGEELEQV YEFMNGAAKE EVGAEKQFDI LSKAVNSYNK ILTEEDQQMR RLAIALQKEI
     GERTHVETAM VKEYRNKIDA LKSAIEIERD GMQEEAIQEI AGMTADVLEA ASEEVPLIGA
     GMATAVATGR AIEGAYKLKK VINALSGIDL THLRTPKIEP SVVSTILEYR AKDIPDNALA
     VSVLSKNRAI QENHKELMHI KDEILPRFKK AMDEEKEICG IEDKTIHPKV MMKFKIPRSQ
     QPQIHIYTAP WDSDDVFFFH CISHHHANES FFIGFDLSID LVHYEDLTAH WHALGAAQMA
     VGRTLTEAYK EFLKLAISST YGTQMHTRRL IRSKTVHPIY LGSLHYDISF ADLRGNAQRI
     VYDDELQMHI LRGPLHFQRR AILGALKFGC KILGDRLDVP LFLRNP