ID   VP5_EHDV1               Reviewed;         527 AA.
AC   Q01175;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   02-DEC-2020, entry version 60.
DE   RecName: Full=Outer capsid protein VP5;
GN   Name=Segment-6;
OS   Epizootic hemorrhagic disease virus 1 (EHDV-1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33720;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
OH   NCBI_TaxID=9874; Odocoileus virginianus (White-tailed deer).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1662845; DOI=10.1016/0168-1702(91)90081-6;
RA   Iwata H., Hirasawa T., Roy P.;
RT   "Complete nucleotide sequence of segment 5 of epizootic haemorrhagic
RT   disease virus; the outer capsid protein VP5 is homologous to the VP5
RT   protein of bluetongue virus.";
RL   Virus Res. 20:273-281(1991).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family. {ECO:0000305}.
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DR   EMBL; X55782; CAA39303.1; -; Genomic_RNA.
DR   PIR; S18762; S18762.
DR   SMR; Q01175; -.
DR   GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039665; P:permeabilization of host organelle membrane involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099008; P:viral entry via permeabilization of inner membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Outer capsid protein;
KW   Viral penetration into host cytoplasm;
KW   Viral penetration via permeabilization of host membrane; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..527
FT                   /note="Outer capsid protein VP5"
FT                   /id="PRO_0000222719"
FT   REGION          1..42
FT                   /note="Involved in membrane permeabilization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   527 AA;  59120 MW;  8651D7346FBD3631 CRC64;
     MGKFIKQLSK FGKKVGGALT SNTAKKIYKT IGDTAVRFAE SDIGSAAIDG LIQGSVESVL
     TGESYGETVK RAVLLNVLGA GDEIPDPLSP GEQGIQRKIK ELEDEMKGEV VRTKHNEQII
     RRFGADLDEV YKFAVSEYKE GVEEKDQFEI LKKALTSYGE LTKAEFGELK RLEKALQKES
     SERSKDESMM VKEYRQKIEA LKDAIEVEST GIQEEAIQEI AGMSADILES AAEEVPLFGG
     GVATSIATAR AIEGGYKLKK VINALSGIDL SHLRTPKIQP KTLEAILEAP TKEEIKDLSL
     VEGIQMKLQN LEENRNEVLH IQEEILPKLR EAMIEDHKEI GDERDKRILP KTAMRFKVPT
     TQQPVIQIYS APWDSDDVFM FHCISHHHLN ESSFLGFDLE LEYVHYEDLT RHWHALGAAQ
     EVTGRSLKEA YSEFFQLAAQ IDGAGAIHQK RLIRSKSYHP IYLGAMHYDI AYRELKNNAL
     KIVNDSEVQK HLLRGPKHFQ RRAILSALKD GVKLLGGVDL AEFMRYA