ID   VP5_IBDV5               Reviewed;         145 AA.
AC   P25221;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   02-JUN-2021, entry version 42.
DE   RecName: Full=Protein VP5;
GN   Name=VP5;
OS   Avian infectious bursal disease virus (strain 52/70) (IBDV) (Gumboro
OS   disease virus).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Avibirnavirus.
OX   NCBI_TaxID=10996;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2161902; DOI=10.1099/0022-1317-71-6-1303;
RA   Bayliss C.D., Spies U., Shaw K., Peters R.W., Papageorgiou A., Mueller H.,
RA   Boursnell M.E.G.;
RT   "A comparison of the sequences of segment A of four infectious bursal
RT   disease virus strains and identification of a variable region in VP2.";
RL   J. Gen. Virol. 71:1303-1312(1990).
CC   -!- FUNCTION: Plays a role in the release of virion progenies by disrupting
CC       the host plasma membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the avibirnavirus/aquabirnavirus VP5 protein
CC       family. {ECO:0000305}.
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DR   EMBL; D00869; BAA00744.1; -; Genomic_RNA.
DR   PIR; JQ0942; JQ0942.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004284; Birna_VP5.
DR   Pfam; PF03042; Birna_VP5; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Protein VP5"
FT                   /id="PRO_0000221965"
FT   TOPO_DOM        1..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..145
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   145 AA;  16633 MW;  C8DF1276400C625D CRC64;
     MVSRDQTNDR SDDKPARSNP TDCSVHTEPS DANNRTGVHS GRHPGEAHSQ VRDLDLQFDC
     GGHRVRANCL FPWIPWLNCG CSLHTAEQWE LQVRSDAPDC PEPTGQLQLL QTSESESHSE
     VKHTPWWRLC TKRHHKRRDL PRKPE