ID   VP5_IBDVB               Reviewed;         145 AA.
AC   P0C751;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Protein VP5;
GN   Name=VP5;
OS   Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998)
OS   (IBDV) (Gumboro disease virus).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Avibirnavirus.
OX   NCBI_TaxID=645118;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9603319; DOI=10.1099/0022-1317-79-5-1047;
RA   Fernandez-Arias A., Risco C., Martinez S., Albar J.P., Rodriguez J.F.;
RT   "Expression of ORF A1 of infectious bursal disease virus results in the
RT   formation of virus-like particles.";
RL   J. Gen. Virol. 79:1047-1054(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7688411; DOI=10.1099/0022-1317-74-8-1563;
RA   Schnitzler D., Bernstein F., Muller H., Becht H.;
RT   "The genetic basis for the antigenicity of the VP2 protein of the
RT   infectious bursal disease virus.";
RL   J. Gen. Virol. 74:1563-1571(1993).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11080482; DOI=10.1006/viro.2000.0595;
RA   Lombardo E., Maraver A., Espinosa I., Fernandez-Arias A., Rodriguez J.F.;
RT   "VP5, the nonstructural polypeptide of infectious bursal disease virus,
RT   accumulates within the host plasma membrane and induces cell lysis.";
RL   Virology 277:345-357(2000).
CC   -!- FUNCTION: Plays a role in the release of virion progenies by disrupting
CC       the host plasma membrane. {ECO:0000269|PubMed:11080482}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000269|PubMed:11080482};
CC       Single-pass membrane protein {ECO:0000269|PubMed:11080482}.
CC   -!- SIMILARITY: Belongs to the avibirnavirus/aquabirnavirus VP5 protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF140705; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000007429; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004284; Birna_VP5.
DR   Pfam; PF03042; Birna_VP5; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Protein VP5"
FT                   /id="PRO_0000378414"
FT   TOPO_DOM        1..68
FT                   /note="Cytoplasmic"
FT   TRANSMEM        69..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..145
FT                   /note="Extracellular"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   145 AA;  16519 MW;  D3CF21C02B13E542 CRC64;
     MVSRDQTNDR SDDKPVRSNP ADCSVHTEPS DANNRTGVHS GRHPGEAHSQ VRDLDLQFDC
     GGHRVRANCL FPWIPWLNCG CSLHTAGQWE LQVRSDAPDC PEPTGQLQLL QASESESHSE
     VKHTSWWRLC TKRHHKRRDL PRKPE