ID   VP5_IBDVU               Reviewed;         149 AA.
AC   Q82634;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 49.
DE   RecName: Full=Protein VP5;
GN   Name=VP5;
OS   Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989)
OS   (IBDV) (Gumboro disease virus).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Avibirnavirus.
OX   NCBI_TaxID=644440;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8725117; DOI=10.1016/0168-1702(95)01253-2;
RA   Brown M.D., Skinner M.A.;
RT   "Coding sequences of both genome segments of a European 'very virulent'
RT   infectious bursal disease virus.";
RL   Virus Res. 40:1-15(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=94432;
RA   Le Nouen C., Rivallan G., Toquin D., Morin Y., Eterradossi N.;
RT   "Natural mutations in the coding sequence of genome segment A of an
RT   infectious bursal disease virus strain related to very virulent viruses
RT   result in loss of pathogenicity.";
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the release of virion progenies by disrupting
CC       the host plasma membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the avibirnavirus/aquabirnavirus VP5 protein
CC       family. {ECO:0000305}.
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DR   EMBL; X92760; CAA63415.1; -; Genomic_RNA.
DR   EMBL; AM167550; CAJ44474.1; -; Genomic_RNA.
DR   RefSeq; NP_690837.1; NC_004178.1.
DR   GeneID; 956508; -.
DR   KEGG; vg:956508; -.
DR   Proteomes; UP000007249; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004284; Birna_VP5.
DR   Pfam; PF03042; Birna_VP5; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..149
FT                   /note="Protein VP5"
FT                   /id="PRO_0000378413"
FT   TOPO_DOM        1..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   149 AA;  17177 MW;  0255CE068C662662 CRC64;
     MLSLMVSRDQ TNDRSDDKPA RSNPTDCSVH TEPSDANNRT GVHSGRHPRE AHSQVRDLDL
     QFDCGGHRVR ANCLFPWLPW LNCGCSLHTA EQWELQVRSD APDCPEPTGQ LQLLQASESE
     SHSEVKHTPW WRLCTKWHHK RRDLPRKPE