ID   VP5_IPNVS               Reviewed;         133 AA.
AC   Q6U2P6; Q69CI1; Q69CI4; Q6U2N6; Q6U2N9; Q6U2P2; Q6U2P8; Q6UAY8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 25.
DE   RecName: Full=Protein VP5;
GN   Name=VP5;
OS   Infectious pancreatic necrosis virus (strain Sp) (IPNV).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Aquabirnavirus.
OX   NCBI_TaxID=11005;
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8028; Salmo.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate NVI-001, Isolate NVI-011, Isolate NVI-013, Isolate NVI-015,
RC   Isolate NVI-016, Isolate NVI-020, and Isolate NVI-023;
RX   PubMed=15063114; DOI=10.1016/j.virol.2003.12.016;
RA   Santi N., Vakharia V.N., Evensen O.;
RT   "Identification of putative motifs involved in the virulence of infectious
RT   pancreatic necrosis virus.";
RL   Virology 322:31-40(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Sp103, Isolate Sp116, and Isolate Sp122;
RX   PubMed=15584407; DOI=10.3354/dao061023;
RA   Shivappa R.B., Song H., Yao K., Aas-Eng A., Evensen O., Vakharia V.N.;
RT   "Molecular characterization of Sp serotype strains of infectious pancreatic
RT   necrosis virus exhibiting differences in virulence.";
RL   Dis. Aquat. Organ. 61:23-32(2004).
RN   [3]
RP   FUNCTION.
RC   STRAIN=Isolate Sp103;
RX   PubMed=15994815; DOI=10.1128/jvi.79.14.9206-9216.2005;
RA   Santi N., Song H., Vakharia V.N., Evensen O.;
RT   "Infectious pancreatic necrosis virus VP5 is dispensable for virulence and
RT   persistence.";
RL   J. Virol. 79:9206-9216(2005).
RN   [4]
RP   FUNCTION.
RC   STRAIN=Isolate NVI-015, Isolate NVI-015-15K, and Isolate NVI-015-DeltaVP5;
RX   PubMed=16126243; DOI=10.1016/j.virol.2005.07.028;
RA   Santi N., Sandtro A., Sindre H., Song H., Hong J.-R., Thu B., Wu J.-L.,
RA   Vakharia V.N., Evensen O.;
RT   "Infectious pancreatic necrosis virus induces apoptosis in vitro and in
RT   vivo independent of VP5 expression.";
RL   Virology 342:13-25(2005).
CC   -!- FUNCTION: VP5 is not required for viral replication in vivo and its
CC       absence does not alter the virulence characteristics of the virus or
CC       the establishment of persistent IPNV infection.
CC       {ECO:0000269|PubMed:15994815, ECO:0000269|PubMed:16126243}.
CC   -!- MISCELLANEOUS: The sequence shown is that of Isolate NVI-020. The
CC       highly pathogenic isolates NVI-013, NVI-015, NVI-023 and Sp122 have a
CC       truncated VP5 protein.
CC   -!- SIMILARITY: Belongs to the avibirnavirus/aquabirnavirus VP5 protein
CC       family. {ECO:0000305}.
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DR   EMBL; AY379735; AAQ75349.1; -; Genomic_RNA.
DR   EMBL; AY374435; AAQ75365.1; -; Genomic_RNA.
DR   EMBL; AY379736; AAQ75351.1; -; Genomic_RNA.
DR   EMBL; AY379737; AAQ75353.1; -; Genomic_RNA.
DR   EMBL; AY379738; AAQ75355.1; -; Genomic_RNA.
DR   EMBL; AY379740; AAQ75358.1; -; Genomic_RNA.
DR   EMBL; AY379742; AAQ75361.1; -; Genomic_RNA.
DR   EMBL; AY354519; AAR10445.1; -; Genomic_RNA.
DR   EMBL; AY354520; AAR10448.1; -; Genomic_RNA.
DR   EMBL; AY354521; AAR10451.1; -; Genomic_RNA.
DR   InterPro; IPR004284; Birna_VP5.
DR   Pfam; PF03042; Birna_VP5; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..133
FT                   /note="Protein VP5"
FT                   /id="PRO_0000227882"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         13
FT                   /note="P -> L (in strain: Isolate NVI-016)"
FT   VARIANT         36
FT                   /note="L -> P (in strain: Isolate NVI-011, Isolate NVI-013
FT                   and Isolate Sp116)"
FT   VARIANT         45
FT                   /note="L -> P (in strain: Isolate NVI-001 and Isolate NVI-
FT                   011)"
FT   VARIANT         68
FT                   /note="C -> R (in strain: Isolate NVI-016)"
FT   VARIANT         100
FT                   /note="A -> V (in strain: Isolate Sp103)"
FT   VARIANT         102
FT                   /note="L -> F (in strain: Isolate NVI-013)"
FT   VARIANT         106..133
FT                   /note="Missing (in strain: Isolate NVI-013, Isolate NVI-
FT                   015, Isolate NVI-023, Isolate Sp122)"
FT   VARIANT         129..133
FT                   /note="Missing (in strain: Isolate NVI-011)"
FT   VARIANT         130
FT                   /note="R -> G (in strain: Isolate Sp103)"
FT   VARIANT         132
FT                   /note="S -> P (in strain: Isolate NVI-001)"
SQ   SEQUENCE   133 AA;  15402 MW;  7BA7FDF9CFCB7EDB CRC64;
     MQDEHKQGNR NLPEIHYASR DWTSKHPGRH NGETHLKTRD LVIQLRGLRI RKWHSCLFPW
     GTRLTDRCTL QMECEPDGAG VRPVAGDVAG PEESLQLREA DLKEIRHPKL HTTGRSLCSE
     RDAQRCHLRR QSV