VP602_ARATH
ID VP602_ARATH Reviewed; 235 AA.
AC Q9FMC5; Q8L964;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Vacuolar protein sorting-associated protein 60.2 {ECO:0000305};
GN Name=VPS60-2 {ECO:0000305}; Synonyms=VPS60B {ECO:0000303|PubMed:22639582};
GN OrderedLocusNames=At5g04850 {ECO:0000312|Araport:AT5G04850};
GN ORFNames=MUK11_17 {ECO:0000312|EMBL:BAB08989.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION, AND REVIEW.
RX PubMed=16488176; DOI=10.1016/j.tplants.2006.01.008;
RA Winter V., Hauser M.-T.;
RT "Exploring the ESCRTing machinery in eukaryotes.";
RL Trends Plant Sci. 11:115-123(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22639582; DOI=10.3389/fpls.2011.00020;
RA Richardson L.G., Howard A.S., Khuu N., Gidda S.K., McCartney A.,
RA Morphy B.J., Mullen R.T.;
RT "Protein-protein interaction network and subcellular localization of the
RT Arabidopsis thaliana ESCRT machinery.";
RL Front. Plant Sci. 2:20-20(2011).
CC -!- FUNCTION: Probable peripherally associated component of the endosomal
CC sorting required for transport complex III (ESCRT-III) which is
CC involved in multivesicular bodies (MVBs) formation and sorting of
CC endosomal cargo proteins into MVBs. {ECO:0000305|PubMed:16488176}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000250|UniProtKB:Q9LPN5}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9LPN5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=Additional isoforms seem to exist. {ECO:0000305};
CC Name=1;
CC IsoId=Q9FMC5-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR EMBL; AB008271; BAB08989.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90794.1; -; Genomic_DNA.
DR EMBL; AF370241; AAK44056.1; -; mRNA.
DR EMBL; AY142614; AAN13183.1; -; mRNA.
DR EMBL; AY088616; AAM66939.1; -; mRNA.
DR RefSeq; NP_568143.1; NM_120567.3. [Q9FMC5-1]
DR AlphaFoldDB; Q9FMC5; -.
DR SMR; Q9FMC5; -.
DR PRIDE; Q9FMC5; -.
DR EnsemblPlants; AT5G04850.1; AT5G04850.1; AT5G04850. [Q9FMC5-1]
DR GeneID; 830364; -.
DR Gramene; AT5G04850.1; AT5G04850.1; AT5G04850. [Q9FMC5-1]
DR KEGG; ath:AT5G04850; -.
DR Araport; AT5G04850; -.
DR HOGENOM; CLU_079409_0_0_1; -.
DR OMA; MEQAQTM; -.
DR PhylomeDB; Q9FMC5; -.
DR PRO; PR:Q9FMC5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMC5; baseline and differential.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR22761; PTHR22761; 1.
DR Pfam; PF03357; Snf7; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Endosome; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..235
FT /note="Vacuolar protein sorting-associated protein 60.2"
FT /id="PRO_0000440686"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..148
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="A -> T (in Ref. 4; AAM66939)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="E -> K (in Ref. 4; AAM66939)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 26238 MW; 2999DF59878CAD4E CRC64;
MKRIFGAKNN KEPPPSIQDA SDRINKRGDS VEEKVKRLDA ELCKYKDQIK RTRPGPALEA
IKARAMRVLK QKKMYEGQRD MLYNQTFNLD QVSFAAEGLK DAQQTMTALK SANKELKGMM
KTVKIQDIDN LQDDMMDLMD ESSEIQETLG RSYNVPDDID EDDLLGELDA LEADMGNETE
ADGVPSYLQP DKEPDLNDEL NLPSAPMGHT GAPPGRAQAE DEWGLPAVPR ASLRG
