ID   VP6A_BTV10              Reviewed;         329 AA.
AC   Q98829; P23066; Q6LCJ9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Protein VP6-A;
DE   AltName: Full=Minor inner core protein VP6-A;
GN   Name=Segment-9;
OS   Bluetongue virus 10 (isolate USA) (BTV 10).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10900;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2544660; DOI=10.1099/0022-1317-70-7-1677;
RA   Fukusho A., Yu Y., Yamaguchi S., Roy P.;
RT   "Completion of the sequence of bluetongue virus serotype 10 by the
RT   characterization of a structural protein, VP6, and a non-structural
RT   protein, NS2.";
RL   J. Gen. Virol. 70:1677-1689(1989).
RN   [2]
RP   SEQUENCE REVISION.
RA   Blachere C.;
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate 10O80Z, and isolate BTV10;
RX   PubMed=8764098; DOI=10.1128/jvi.70.8.5735-5739.1996;
RA   de Mattos C.C., de Mattos C.A., MacLachlan N.J., Giavedoni L.D., Yilma T.,
RA   Osburn B.I.;
RT   "Phylogenetic comparison of the S3 gene of United States prototype strains
RT   of bluetongue virus with that of field isolates from California.";
RL   J. Virol. 70:5735-5739(1996).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Protein VP6-A;
CC         IsoId=Q98829-1; Sequence=Displayed;
CC       Name=Protein VP6-B;
CC         IsoId=P33423-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the reoviruses VP6 family. {ECO:0000305}.
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DR   EMBL; D00509; BAA00399.2; -; Genomic_RNA.
DR   EMBL; U55781; AAC55309.1; -; Genomic_RNA.
DR   EMBL; U55801; AAC55329.1; -; Genomic_RNA.
DR   Proteomes; UP000007662; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Alternative initiation; Reference proteome; Virion.
FT   CHAIN           1..329
FT                   /note="Protein VP6-A"
FT                   /id="PRO_0000372866"
FT   REGION          28..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  35530 MW;  71B6EF82DC19DB18 CRC64;
     MSAAILLAPG DVIKRSSEEL KQRQIQINLV DWMESEGGKE DKTEPKEESK AEGSKDGEGT
     QSESGQKEEG GKETKDADVD RRIHTAVGSG SGTKGSGERA NENANRGDGK VGGGGGDADA
     GVGATGTNGG RWVVLTEEIA RAIESKYGTK IDVYRDEVPA QIIEVERSLQ KELGISREGV
     AEQTERLRDL RRKEKNGTHA KAVERGGRKQ RKKAHGDAQR EGVEEEKTSE EPARIGITIE
     GVMSQKKLLS MIGGVERKMA PIGARESAVM LVSNSIKDVV RATAYFTAPT GDPHWKEVAR
     EASKKKNILA YTSTGGDVKT EFLHLIDHL