ID   VP6B_BTV10              Reviewed;         325 AA.
AC   P33423;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   02-JUN-2021, entry version 54.
DE   RecName: Full=Protein VP6-B;
DE   AltName: Full=Minor inner core protein VP6-B;
GN   Name=Segment-9;
OS   Bluetongue virus 10 (isolate USA) (BTV 10).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10900;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1329371; DOI=10.1016/0168-1702(92)90126-t;
RA   Hwang G.-Y., Chiou J.-F., Yang Y.-Y., Li J.K.-K.;
RT   "Comparative sequence analyses of the cognate structural protein VP6 genes
RT   of five US bluetongue viruses.";
RL   Virus Res. 24:315-323(1992).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Protein VP6-B;
CC         IsoId=P33423-1; Sequence=Displayed;
CC       Name=Protein VP6-A;
CC         IsoId=Q98829-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the orbivirus VP6 family. {ECO:0000305}.
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DR   EMBL; L08669; AAA42818.1; -; Genomic_RNA.
DR   PIR; B48561; B48561.
DR   Proteomes; UP000007662; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Alternative initiation; Reference proteome; Virion.
FT   CHAIN           1..325
FT                   /note="Protein VP6-B"
FT                   /id="PRO_0000222723"
FT   REGION          23..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  35163 MW;  AC759B7005DACD5A CRC64;
     MLLAPGDVIK RSSEELKQRQ IQINLIDWIE SESGKEDKAE PKEESKAEES KDGQGTQSES
     SQKKEGSKEA KDADVDRRIH TAVGSGSSAK GPGVRANENV DRGDGKVGGG GGNADAGVGT
     IGANGGRWVV LTEEIARAIE SKYGTKIDVY RDKVPAQIIE VERSLQKELG ISREGVAEQT
     ERLRDLRRKE KSGAHAKAAE RGRRKQGKKP HGDVQKEGTE EEKTSEEQAS VGIAIEGVMS
     QKKLLSMIGG VERKMAPIGA RESAVMLVSN SIKDVVRATA YFTAPTGDPH WKEVAREASK
     KKNILAYTST GGDVKTEFLH LIDHL