ID   VP6_APRVF               Reviewed;         540 AA.
AC   Q2Y0E5;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   02-DEC-2020, entry version 30.
DE   RecName: Full=Microtubule-associated protein VP6;
GN   Name=S6;
OS   Aedes pseudoscutellaris reovirus (isolate France) (ApRV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Dinovernavirus.
OX   NCBI_TaxID=648170;
OH   NCBI_TaxID=316597; Aedes pseudoscutellaris (Mosquito) (Stegomyia pseudoscutellaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16171838; DOI=10.1016/j.virol.2005.08.028;
RA   Attoui H., Mohd Jaafar F., Belhouchet M., Biagini P., Cantaloube J.F.,
RA   de Micco P., de Lamballerie X.;
RT   "Expansion of family Reoviridae to include nine-segmented dsRNA viruses:
RT   isolation and characterization of a new virus designated Aedes
RT   pseudoscutellaris reovirus assigned to a proposed genus (Dinovernavirus).";
RL   Virology 343:212-223(2005).
CC   -!- FUNCTION: Minor inner capsid component. Displays NTPase and RNA 5'-
CC       triphosphatase (RTPase) activities. May function as a cofactor of
CC       polymerase VP2. Associates with microtubules and plays a role in the
CC       formation, structural organization and morphology of viral inclusions,
CC       where the assembly of cores and the replication of viral RNA occur (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VP2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm, host
CC       cytoskeleton {ECO:0000250}.
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DR   EMBL; DQ087281; AAZ94073.1; -; Genomic_RNA.
DR   RefSeq; YP_443940.1; NC_007671.1.
DR   GeneID; 5076693; -.
DR   KEGG; vg:5076693; -.
DR   Proteomes; UP000001676; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Capsid protein; Host cytoplasm; Host cytoskeleton; Inner capsid protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..540
FT                   /note="Microtubule-associated protein VP6"
FT                   /id="PRO_0000403280"
SQ   SEQUENCE   540 AA;  62224 MW;  63F4352EC927129C CRC64;
     MFAIPFTASQ VYSHLGLYLQ PIEKLDPLTK VQYESAEKLR DIIAQLSRRS GGISLRKNLI
     RDIACGHKPK LNIPSLTHQV RHNREFKHGR SQFILVDSNG SDYYDGIFDD MVLILQSNFV
     LPNVPGIISE QLRLIVIDND FYLKHIPSEI AILRDVLSEH MVKFSIDGVS LEDPFISKFF
     RKPFVLYDHT KFKKIDLTKV VLINKTGKSK AQVIDKYKLN DDAVFINYEV FDVMLQPTKR
     RDGDIEQFIR MRGDIETWKA KIGTTFEDNL LELFVHGVPV MNSTSQLQLD FQISDIRVAS
     VFDDQIVCAS KLNSLREQCL TESSLIRVNI IGQKGSGKSM LMKLINERGI PGISRRIICI
     DSDAYGKWRT QTQYIDNKFE ALKLINVDNL YEIARDDSVV SFYEQFIIDQ LLSHNIEISE
     HTNSLRFIKQ LKVDILKDIG RKFKEMYLAD FKEQGQFYEY LCGNMPEPSN TLLITFLHAT
     VETSAAPGTN MNFSLNTILY PLQSILNRKR GTLVNFILNR IYDEMGTEAF TRLRPCDVWK