ID   VP6_BTV17               Reviewed;         325 AA.
AC   P32935;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Protein VP6;
DE   AltName: Full=Minor inner core protein VP6;
GN   Name=Segment-9;
OS   Bluetongue virus 17 (isolate USA) (BTV 17).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33718;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1329371; DOI=10.1016/0168-1702(92)90126-t;
RA   Hwang G.-Y., Chiou J.-F., Yang Y.-Y., Li J.K.-K.;
RT   "Comparative sequence analyses of the cognate structural protein VP6 genes
RT   of five US bluetongue viruses.";
RL   Virus Res. 24:315-323(1992).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- SIMILARITY: Belongs to the orbivirus VP6 family. {ECO:0000305}.
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DR   EMBL; L08672; AAA42821.1; -; Genomic_RNA.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..325
FT                   /note="Protein VP6"
FT                   /id="PRO_0000222726"
FT   REGION          1..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..229
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  35317 MW;  6E0C5986A2DA11C1 CRC64;
     MLLAPGDVIK RSSEELKQRQ IQINLVDWAE SEGGKEDKTE PKEESKAEGS KDGEGTQSES
     GQKEEGGKET KDADVDRRIH TAVGSGSSTK GLGERANENA DRGDGKVGGG GGDADAGVGA
     TGTNGRRWVV LTEEIARAIE SKYGTKIDVY RDEVPAQIIE VERSLQKELG ISREGVAEQT
     ERLRDLRRKE KNGTHAKAVE RGGRKQRKKT HGDAQREGVE EEKTSEEPAR IGITIEGVMS
     QKKLLSMIGG VERKMAPIGA RESAVMLVSN SIKDVMRATA YFTAPTGDPH WKEVAREASK
     KKNILAYTST GGDAKTEFLH LIDHL