ID   VP6_BTV1S               Reviewed;         328 AA.
AC   Q03328; Q65752;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   02-JUN-2021, entry version 51.
DE   RecName: Full=Protein VP6;
DE   AltName: Full=Minor inner core protein VP6;
GN   Name=Segment-9;
OS   Bluetongue virus 1 (isolate South Africa) (BTV 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10905;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1331303; DOI=10.1099/0022-1317-73-11-3023;
RA   Wade-Evans A.M., Mertens P.P.C., Belsham G.J.;
RT   "Sequence of genome segment 9 of bluetongue virus (serotype 1, South
RT   Africa) and expression analysis demonstrating that different forms of VP6
RT   are derived from initiation of protein synthesis at two distinct sites.";
RL   J. Gen. Virol. 73:3023-3026(1992).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=VP6;
CC         IsoId=Q03328-1; Sequence=Displayed;
CC       Name=VP6A;
CC         IsoId=Q03328-2; Sequence=VSP_018958;
CC   -!- SIMILARITY: Belongs to the orbivirus VP6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA01714.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D10905; BAA01713.1; -; Genomic_RNA.
DR   EMBL; D10905; BAA01714.1; ALT_INIT; Genomic_RNA.
DR   PIR; JQ1875; JQ1875.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Alternative initiation; Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..328
FT                   /note="Protein VP6"
FT                   /id="PRO_0000040620"
FT   REGION          31..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..4
FT                   /note="Missing (in isoform VP6A)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018958"
SQ   SEQUENCE   328 AA;  35928 MW;  3E266DBFF937B094 CRC64;
     MSAAMLLAPG DVIKRSSEEL KQRQIQINLT DWTEGETNKE SKAERKEGDK AEELKDGEGR
     NRRAARRKRA AKETKDARCD RRIHTAVGSG SSAKGPGERA NENVDRGDGK VGGGGGDADA
     GVGTTGANGG RWVVLTEEIR RAIESKYGTK IDVYRDEVPA QIIEVERSLQ KELGISREGV
     AEQTERLRDL RRKEKSGAHA KAAERGRRKQ GKKPHGDAQR EGPEEEKTSE EPASVGITIE
     GVMSQKKLLS MIGGVERKMA PIGARESAVM LVSNSIKDVV RATAYFTAPT GDPHWKEVAA
     KLQKRRTIRY TSTGGDVKTE FLHLIDHL