ID   VP6_BTV2A               Reviewed;         301 AA.
AC   P33422;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Protein VP6;
DE   AltName: Full=Minor inner core protein VP6;
GN   Name=Segment-9;
OS   Bluetongue virus 2 (isolate USA) (BTV 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10907;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1329371; DOI=10.1016/0168-1702(92)90126-t;
RA   Hwang G.-Y., Chiou J.-F., Yang Y.-Y., Li J.K.-K.;
RT   "Comparative sequence analyses of the cognate structural protein VP6 genes
RT   of five US bluetongue viruses.";
RL   Virus Res. 24:315-323(1992).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- SIMILARITY: Belongs to the orbivirus VP6 family. {ECO:0000305}.
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DR   EMBL; L08668; AAA42822.1; -; Genomic_RNA.
DR   PRIDE; P33422; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..301
FT                   /note="Protein VP6"
FT                   /id="PRO_0000222721"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  32864 MW;  60720F0E7D3FE834 CRC64;
     MIDWAESESG KGDKVEPKEE NEAEESKDGE GTQSESGQKK ESSKEAEDAD VDRRVHTTVG
     SGSGAKGFRE RANENVDRGD GKVCGGVGDV DAGVGTTGTN GGRWVVLTEE IARAIESKYG
     TKIDVYRDEV PAQIIEVERS LQKELGISRE GVAEQTERLR DLRRKEKSET HARVAEKGRR
     KQGKRVHGDA QKESTEDEKT PEEPTSVGIT IEGVMSQKKL LSMIGGVERK MAPIGARESA
     VMLVSNSIKD VVRATAYFTA PTGDPHWKEV AREASKKKNI LAYTSTGGDV KTEFLHLIDH
     L