ID   VP6_BTVBZ               Reviewed;         329 AA.
AC   P0C6L1; P23066; Q6LCJ9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   02-JUN-2021, entry version 21.
DE   RecName: Full=Protein VP6;
DE   AltName: Full=Minor inner core protein VP6;
GN   Name=Segment-9;
OS   Bluetongue virus 13 (isolate 13B89Z) (BTV 13).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=355314;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=13B89Z;
RX   PubMed=8764098; DOI=10.1128/jvi.70.8.5735-5739.1996;
RA   de Mattos C.C., de Mattos C.A., MacLachlan N.J., Giavedoni L.D., Yilma T.,
RA   Osburn B.I.;
RT   "Phylogenetic comparison of the S3 gene of United States prototype strains
RT   of bluetongue virus with that of field isolates from California.";
RL   J. Virol. 70:5735-5739(1996).
CC   -!- FUNCTION: Surrounds and interacts with the genomic dsRNA. Possesses
CC       ss- and dsRNA-binding capacity. Its hydrophilic nature and capability
CC       to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Inner capsid.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Protein VP6;
CC         IsoId=P0C6L1-1; Sequence=Displayed;
CC       Name=Protein NS4;
CC         IsoId=P0DJZ7-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the reoviruses VP6 family. {ECO:0000305}.
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DR   EMBL; U55791; AAC55319.1; -; Genomic_RNA.
DR   RefSeq; YP_052953.1; NC_006008.1.
DR   GeneID; 2943150; -.
DR   KEGG; vg:2943150; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001399; Orbi_VP6.
DR   Pfam; PF01516; Orbi_VP6; 1.
DR   PRINTS; PR00902; VP6CAPSID.
PE   3: Inferred from homology;
KW   Alternative initiation; Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..329
FT                   /note="Protein VP6"
FT                   /id="PRO_0000222722"
FT   REGION          27..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  35516 MW;  5BDA9E4407E23430 CRC64;
     MSAAILLAPG DVIKRSSEEL KQRQIQINLV DWMESEGGKE DKTEPKEESK AEGSKDGEGT
     QSESGQKEEG GKETKDADVD RRIHTAVGSG SGTKGSGERA NENANRGDGK VGGGGGDADA
     GVGATGTNGG RWVVLTEEIA RAIESKYGTK IDVYRDDVPA QIIEVERSLQ KELGISREGV
     AEQTERLRDL RRKEKNGTHA KAVERGGRKQ RKKAHGDAQR EGVEEEKTSE EPARIGITIE
     GVMSQKKLLS MIGGVERKMA PIGARESAVM LVSNSIKDVV RATAYFTAPT GDPHWKEVAR
     EASKKKNILA YTSTGGDVKT EFLHLIDHL