VP7_AHSV4
ID VP7_AHSV4 Reviewed; 350 AA.
AC P36325;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Core protein VP7;
DE AltName: Full=Capsid protein VP7;
DE AltName: Full=VP7 antigen;
GN Name=Segment-7;
OS African horse sickness virus 4 (AHSV-4).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=36421;
OH NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Vaccine;
RX PubMed=1646273; DOI=10.1099/0022-1317-72-6-1237;
RA Roy P., Hirasawa T., Fernandez M., Blinov V.M.,
RA Sanchez-Vixcain Rodrique J.M.;
RT "The complete sequence of the group-specific antigen, VP7, of African
RT horsesickness disease virus serotype 4 reveals a close relationship to
RT bluetongue virus.";
RL J. Gen. Virol. 72:1237-1241(1991).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), AND SEQUENCE REVISION TO 207.
RC STRAIN=Vaccine;
RX PubMed=8648715; DOI=10.1128/jvi.70.6.3797-3806.1996;
RA Basak A.K., Gouet P., Grimes J., Roy P., Stuart D.;
RT "Crystal structure of the top domain of African horse sickness virus VP7:
RT comparisons with bluetongue virus VP7.";
RL J. Virol. 70:3797-3806(1996).
CC -!- FUNCTION: Major structural core protein; binds to structural protein
CC VP3. Constitutes the surface of the AHSV core.
CC -!- SUBUNIT: Homotrimer.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP7 family. {ECO:0000305}.
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DR EMBL; D12533; BAA02096.1; -; Genomic_RNA.
DR EMBL; X56676; CAA39999.1; -; mRNA.
DR PIR; JQ1946; JQ1946.
DR PDB; 1AHS; X-ray; 2.30 A; A/B/C=126-251.
DR PDBsum; 1AHS; -.
DR SMR; P36325; -.
DR EvolutionaryTrace; P36325; -.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR Gene3D; 1.10.170.10; -; 1.
DR Gene3D; 1.10.250.10; -; 1.
DR InterPro; IPR008980; Capsid_hemagglutn.
DR InterPro; IPR001803; Orbi_VP7_capsid.
DR InterPro; IPR023178; Orbi_VP7_capsid_C.
DR InterPro; IPR023176; Orbi_VP7_capsid_N.
DR InterPro; IPR008935; Virus_capsid_a-hlx_vir.
DR Pfam; PF00897; Orbi_VP7; 1.
DR PRINTS; PR00903; VP7CAPSID.
DR SUPFAM; SSF48345; SSF48345; 1.
DR SUPFAM; SSF49818; SSF49818; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; Glycoprotein; Outer capsid protein; Virion.
FT CHAIN 1..350
FT /note="Core protein VP7"
FT /id="PRO_0000222736"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CONFLICT 207
FT /note="G -> GAPG (in Ref. 1)"
FT /evidence="ECO:0000305"
FT TURN 128..131
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 144..154
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 157..162
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 166..169
FT /evidence="ECO:0007829|PDB:1AHS"
FT HELIX 171..174
FT /evidence="ECO:0007829|PDB:1AHS"
FT TURN 178..180
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 184..195
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 209..212
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 215..217
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 223..225
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 227..229
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 231..235
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 237..239
FT /evidence="ECO:0007829|PDB:1AHS"
FT STRAND 241..250
FT /evidence="ECO:0007829|PDB:1AHS"
SQ SEQUENCE 350 AA; 37942 MW; A58456EFAE5AAB66 CRC64;
MDAIAARALS VVRACVTVTD ARVSLDPGVM ETLGIAINRY NGLTNHSVSM RPQTQAERNE
MFFMCTDMVL AALNVQIGNI SPDYDQALAT VGALATTEIP YNVQAMNDIV RITGQMQTFG
PSKVQTGPYA GAVEVQQSGR YYVPQGRTRG GYINSNIAEV CMDAGAAGQV NALLAPRRGD
AVMIYFVWRP LRIFCDPQGA SLESAPGTFV TVDGVNVAAG DVVAWNTIAP VNVGNPGARR
SILQFEVLWY TSLDRSLDTV PELAPTLTRC YAYVSPTWHA LRAVIFQQMN MQPINPPIFP
PTERNEIVAY LLLVASLADV YAALRPDFRM NGVVAPVGQI NRALVLAAYH
