VP7_BTV1S
ID VP7_BTV1S Reviewed; 349 AA.
AC P18259;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 23-FEB-2022, entry version 93.
DE RecName: Full=Core protein VP7;
GN Name=Segment-7;
OS Bluetongue virus 1 (isolate South Africa) (BTV 1).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=10905;
OH NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2168541; DOI=10.1093/nar/18.16.4919;
RA Wade-Evans A.M.;
RT "The complete nucleotide sequence of genome segment 7 of bluetongue virus,
RT serotype 1 from South Africa.";
RL Nucleic Acids Res. 18:4919-4919(1990).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
RX PubMed=9774103; DOI=10.1038/26694;
RA Grimes J.M., Burroughs J.N., Gouet P., Diprose J.M., Malby R., Zientara S.,
RA Mertens P.P., Stuart D.I.;
RT "The atomic structure of the bluetongue virus core.";
RL Nature 395:470-478(1998).
CC -!- FUNCTION: The VP7 protein is one of the five proteins (with VP1, VP3,
CC VP4, and VP6) which form the inner capsid of the virus.
CC -!- SUBUNIT: Homotrimer that assemble in a complex of 260 capsomers on an
CC inner scaffold composed of VP3.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP7 family. {ECO:0000305}.
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DR EMBL; X53740; CAA37769.1; -; Genomic_RNA.
DR PIR; S11206; S11206.
DR PDB; 2BTV; X-ray; 3.50 A; C/D/E/F/G/H/I/J/P/Q/R/S/T=1-349.
DR PDBsum; 2BTV; -.
DR SMR; P18259; -.
DR DIP; DIP-59521N; -.
DR IntAct; P18259; 2.
DR EvolutionaryTrace; P18259; -.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0039624; C:viral outer capsid; IEA:UniProtKB-KW.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR Gene3D; 1.10.170.10; -; 1.
DR Gene3D; 1.10.250.10; -; 1.
DR InterPro; IPR008980; Capsid_hemagglutn.
DR InterPro; IPR001803; Orbi_VP7_capsid.
DR InterPro; IPR023178; Orbi_VP7_capsid_C.
DR InterPro; IPR023176; Orbi_VP7_capsid_N.
DR InterPro; IPR008935; Virus_capsid_a-hlx_vir.
DR Pfam; PF00897; Orbi_VP7; 1.
DR PRINTS; PR00903; VP7CAPSID.
DR SUPFAM; SSF48345; SSF48345; 1.
DR SUPFAM; SSF49818; SSF49818; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; Glycoprotein; Outer capsid protein; Virion.
FT CHAIN 1..349
FT /note="Core protein VP7"
FT /id="PRO_0000222730"
FT CARBOHYD 287
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT HELIX 2..15
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 20..22
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 27..44
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 56..73
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 90..93
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 103..116
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 128..130
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 133..136
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 148..155
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 158..163
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 168..170
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 172..174
FT /evidence="ECO:0007829|PDB:2BTV"
FT TURN 175..177
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 181..195
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 197..199
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 201..203
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 209..212
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 215..217
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 223..225
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 227..229
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 231..234
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 237..239
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 241..254
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 263..270
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 276..286
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 289..291
FT /evidence="ECO:0007829|PDB:2BTV"
FT STRAND 293..295
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 304..323
FT /evidence="ECO:0007829|PDB:2BTV"
FT HELIX 341..347
FT /evidence="ECO:0007829|PDB:2BTV"
SQ SEQUENCE 349 AA; 38644 MW; 79551F71CB802B0E CRC64;
MDTIAARALT VMRACATLQE ARIVLEANVM EILGIAINRY NGLTLRGVTM RPTSLAQRNE
MFFMCLDMML SAAGINVGPI SPDYTQHMAT IGVLATPEIP FTTEAANEIA RVTGETSTWG
PARQPYGFFL ETEETFQPGR WFMRAAQAAT AVVCGPDMIQ VSLNAGARGD VQQIFQGRND
PMMIYLVWRR IENFAMAQGN SQQTQAGVTV SVGGVDMRAG RIIAWDGQAA LHVRNPTQQN
AMVQIQVVFY ISMDKTLNQY PALTAEIFNV YSFRDHTWHG LRTAIRNRTT LPNMLPPIFP
PNDRDSILTL LLLSTLADVY TVLRPEFAMH GVNPMPWPLT AAIARAAYV
