VP80_NPVAC
ID VP80_NPVAC Reviewed; 691 AA.
AC Q00733;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 29-SEP-2021, entry version 62.
DE RecName: Full=Capsid-associated protein VP80;
GN Name=VP80; ORFNames=ORF104;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HR3;
RX PubMed=1529529; DOI=10.1016/0042-6822(92)91206-a;
RA Lu A., Carstens E.B.;
RT "Nucleotide sequence and transcriptional analysis of the p80 gene of
RT Autographa californica nuclear polyhedrosis virus: a homologue of the
RT Orgyia pseudotsugata nuclear polyhedrosis virus capsid-associated gene.";
RL Virology 190:201-209(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=12904572; DOI=10.1073/pnas.1733972100;
RA Braunagel S.C., Russell W.K., Rosas-Acosta G., Russell D.H., Summers M.D.;
RT "Determination of the protein composition of the occlusion-derived virus of
RT Autographa californica nucleopolyhedrovirus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:9797-9802(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=20444894; DOI=10.1128/jvi.00040-10;
RA Wang R., Deng F., Hou D., Zhao Y., Guo L., Wang H., Hu Z.;
RT "Proteomics of the Autographa californica nucleopolyhedrovirus budded
RT virions.";
RL J. Virol. 84:7233-7242(2010).
RN [5]
RP FUNCTION.
RX PubMed=21449023; DOI=10.1002/bit.23028;
RA Marek M., van Oers M.M., Devaraj F.F., Vlak J.M., Merten O.W.;
RT "Engineering of baculovirus vectors for the manufacture of virion-free
RT biopharmaceuticals.";
RL Biotechnol. Bioeng. 108:1056-1067(2011).
RN [6]
RP FUNCTION, INTERACTION WITH HOST NUCLEAR F-ACTIN, AND SUBCELLULAR LOCATION.
RX PubMed=21450830; DOI=10.1128/jvi.00035-11;
RA Marek M., Merten O.W., Galibert L., Vlak J.M., van Oers M.M.;
RT "Baculovirus VP80 protein and the F-actin cytoskeleton interact and connect
RT the viral replication factory with the nuclear periphery.";
RL J. Virol. 85:5350-5362(2011).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=22090126; DOI=10.1128/jvi.05600-11;
RA Marek M., Merten O.W., Francis-Devaraj F., Oers M.M.;
RT "Essential C-terminal region of the baculovirus minor capsid protein VP80
RT binds DNA.";
RL J. Virol. 86:1728-1738(2012).
CC -!- FUNCTION: Structural protein that plays a role in the packaging of
CC nucleocapsids and in their egress from the nucleus toward the cell
CC periphery. {ECO:0000269|PubMed:21449023, ECO:0000269|PubMed:21450830,
CC ECO:0000269|PubMed:22090126}.
CC -!- SUBUNIT: Homodimer. Interacts with host nuclear F-actin.
CC {ECO:0000269|PubMed:21450830, ECO:0000269|PubMed:22090126}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:21450830,
CC ECO:0000269|PubMed:22090126}. Virion {ECO:0000269|PubMed:12904572,
CC ECO:0000269|PubMed:20444894}. Note=Capsid-associated. Present in both
CC the budded virus (BV) and the occluded virus (OV). The occluded form
CC allows the virus to be transmitted from insect to insect through
CC ingestion of contaminated food while the budded form is responsible for
CC the dissemination of infection throughout the insect host.
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DR EMBL; M94914; AAA46732.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66734.1; -; Genomic_DNA.
DR PIR; A43376; VCNVH3.
DR RefSeq; NP_054134.1; NC_001623.1.
DR PRIDE; Q00733; -.
DR GeneID; 1403937; -.
DR KEGG; vg:1403937; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0046802; P:exit of virus from host cell nucleus by nuclear egress; IDA:UniProtKB.
DR InterPro; IPR009893; Nucleo_P80/P87.
DR Pfam; PF07267; Nucleo_P87; 1.
DR PIRSF; PIRSF003639; Nucleo_P87; 1.
PE 1: Evidence at protein level;
KW Capsid protein; DNA-binding; Host nucleus; Reference proteome; Virion.
FT CHAIN 1..691
FT /note="Capsid-associated protein VP80"
FT /id="PRO_0000132935"
FT REGION 416..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 79879 MW; 17869AB0C740225E CRC64;
MNDSNSLLIT RLAAQILSRN MQTVDVIVDD KTLSLEEKID TLTSMVLAVN SPPQSPPRVT
SSDLAASIIK NNSKMVGNDF EMRYNVLRMA VVFVKHYPKY YNETTAGLVA EIESNLLQYQ
NYVNQGNYQN IEGYDSLLNK AEECYVKIDR LFKESIKKIM DDTEAFEREQ EAERLRAEQT
AANALLERRA QTSADDVVNR ADANIPTAFS DPLPGPSAPR YMYESSESDT YMETARRTAE
HYTDQDKDYN AAYTADEYNS LVKTVLLRLI EKALATLKNR LHITTIDQLK KFRDYLNSDA
DAGEFQIFLN QEDCVILKNL SNLASKFFNV RCVADTLEVM LEALRNNIEL VQPESDAVRR
IVIKMTQEIK DSSTPLYNIA MYKSDYDAIK NKNIKTLFDL YNDRLPINFL DTSATSPVRK
TSGKRSAEDD LLPTRSSKRA NRPEINVISS EDEQEDDDVE DVDYEKESKR RKLEDEDFLK
LKALEFSKDI VNEKLQKIIV VTDGMKRLYE YCNCKNSLET LPSAANYGSL LKRLNLYNLD
HIEMNVNFYE LLFPLTLYND NDNSDKTLSH QLVNYIFLAS NYFQNCAKNF NYMRETFNVF
GPFKQIDFMV MFVIKFNFLC DMRNFAKLID ELVPNKQPNM RIHSVLVMRD KIVKLAFSNL
QFQTFSKKDK SRNTKHLQRL IMLMNANYNV I
