ID   VP8_FOWPN               Reviewed;         253 AA.
AC   P15913;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   02-DEC-2020, entry version 69.
DE   RecName: Full=Core protein VP8;
DE   AltName: Full=25 kDa major core protein;
DE   AltName: Full=L4 core protein;
DE   AltName: Full=P25K;
DE   Flags: Precursor;
GN   OrderedLocusNames=FPV131; ORFNames=FP5;
OS   Fowlpox virus (strain NVSL) (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=928301;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FP-9 / Isolate HP-444;
RX   PubMed=2838574; DOI=10.1099/0022-1317-69-6-1275;
RA   Binns M.M., Tomley F.M., Campbell J., Boursnell M.E.G.;
RT   "Comparison of a conserved region in fowlpox virus and vaccinia virus
RT   genomes and the translocation of the fowlpox virus thymidine kinase gene.";
RL   J. Gen. Virol. 69:1275-1283(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Major core structural protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Undergoes morphogenesis-associated proteolysis which cleaves the
CC       28 kDa to a 25-kDa product. Proteolytic cleavage of major core proteins
CC       P4a (A10L), P4b (A3L), and VP8 (L4R), which occurs at a late stage of
CC       core formation, is required for production of infectious mature virions
CC       (MV) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VP8 family. {ECO:0000305}.
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DR   EMBL; D00320; BAA00228.1; -; Genomic_DNA.
DR   EMBL; AF198100; AAF44475.1; -; Genomic_DNA.
DR   PIR; JS0225; WMVZP5.
DR   RefSeq; NP_039094.1; NC_002188.1.
DR   GeneID; 1486679; -.
DR   KEGG; vg:1486679; -.
DR   Proteomes; UP000008597; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007586; VP8_pox_nuc-bd.
DR   Pfam; PF04498; Pox_VP8_L4R; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   PROPEP          1..31
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000040595"
FT   CHAIN           32..253
FT                   /note="Core protein VP8"
FT                   /id="PRO_0000040596"
FT   SITE            31..32
FT                   /note="Cleavage; by core protease I7"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   253 AA;  28345 MW;  E8E68B0360E6002D CRC64;
     MNDLLLENLF GEKALCAQVT RDQLLEIIAA GARSKFPKSL LSMYRVTPRV MTRYPLKLIT
     NESITGVVIT TVYNLKKNLN IPQNNKLTTQ DIERYYLDKS VEVINLMVGN TSLGDLACGR
     PRRTKSSKKK DPVIFLGISA PLILVMNSKK SINTYIQDKK SDPSSDYVNI NPGIGVLENY
     GNTYLLDIHN PSSVLTISTI YGLDNNMELK KLSTASEIDA YQDVNIGKSV DLKKFNEIFN
     TMKKHLSLSN FSI