ID   VPAP_HHV6G              Reviewed;         388 AA.
AC   P27417;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   02-JUN-2021, entry version 58.
DE   RecName: Full=DNA polymerase processivity factor;
DE   AltName: Full=Phosphoprotein P41;
DE            Short=PP41;
DE   AltName: Full=Polymerase accessory protein;
DE            Short=PAP;
DE   Flags: Fragment;
GN   Name=U27;
OS   Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10369;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1851860; DOI=10.1128/jvi.65.6.2884-2894.1991;
RA   Chang C.K., Balachandran N.;
RT   "Identification, characterization, and sequence analysis of a cDNA encoding
RT   a phosphoprotein of human herpesvirus 6.";
RL   J. Virol. 65:2884-2894(1991).
RN   [2]
RP   SEQUENCE REVISION.
RA   Chang C.K., Balachandran N.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the DNA polymerase that acts to increase
CC       the processivity of polymerization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae polymerase accessory protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA43853.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M62700; AAA43853.1; ALT_INIT; mRNA.
DR   SMR; P27417; -.
DR   PRIDE; P27417; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR004997; Herpes_PAP.
DR   Pfam; PF03325; Herpes_PAP; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Phosphoprotein.
FT   CHAIN           <1..388
FT                   /note="DNA polymerase processivity factor"
FT                   /id="PRO_0000116065"
FT   REGION          20..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   388 AA;  44184 MW;  2B4959E6414899E5 CRC64;
     FFFFKAHKAR VGARTSFLTE MERGSRDHHR DHRDHREHRE TREPPTLAFH MKSWKTINKS
     LKAFAKLLKE NATVTFTPQP SIIIQSAKNH LVQKLTIQAE CLFLSDTDRF LTKTINNHIP
     LFESFMNIIS NPEVTKMYIQ HDSDLYTRVL VTASDTCTQA SVPCVHGQEV VRDTGRSPLR
     IDLDHSTVSD VLKWLSPVTK TKRSGKSDAL MAHIIVQVNP PTIKFVTEMN ELEFSNSNKV
     IFYDVKNMRF NLSAKNLQQA LSMCAVIKTS CSLRTVAAKD CKLILTSKST LLTVEAFLTQ
     EQLKEESRFE RMGKQDDGKG DRSHKNEDGS ALASKQEMQY EITNYMVPAK NGTAGSSLFN
     EKEDSESDDS MHFDYSSNPN PKRQRCVV