ID   VPAP_HHV6U              Reviewed;         393 AA.
AC   P52439; Q69052;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-JUN-2021, entry version 69.
DE   RecName: Full=DNA polymerase processivity factor;
DE   AltName: Full=Phosphoprotein P41;
DE            Short=PP41;
DE   AltName: Full=Polymerase accessory protein;
DE            Short=PAP;
GN   Name=U27; Synonyms=EPLF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Accessory subunit of the DNA polymerase that acts to increase
CC       the processivity of polymerization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae polymerase accessory protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16735.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L25528; AAA16735.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58407.1; -; Genomic_DNA.
DR   PIR; T09322; T09322.
DR   RefSeq; NP_042920.2; NC_001664.2.
DR   SMR; P52439; -.
DR   PRIDE; P52439; -.
DR   DNASU; 1487904; -.
DR   GeneID; 1487904; -.
DR   KEGG; vg:1487904; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR004997; Herpes_PAP.
DR   Pfam; PF03325; Herpes_PAP; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Phosphoprotein; Reference proteome.
FT   CHAIN           1..393
FT                   /note="DNA polymerase processivity factor"
FT                   /id="PRO_0000116066"
FT   REGION          25..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        377..393
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  44810 MW;  239ADFF63F645D90 CRC64;
     MCWSFHLFFK AHKARVGART SFLTEMERGS RDHHRDHRDH REHRETREPP TLAFHMKSWK
     TINKSLKAFA KLLKENTTVT FTPQPSIIIQ SAKNHLVQKL TIQAECLFLS DTDRFLTKTI
     NNHIPLFESF MNIISNPEVT KMYIQHDSDL YTRVLVTASD TCTQASVPCV HGQEVVRDTG
     RSPLRIDLDH STVSDVLKWL SPVTKTKRSG KSDALMAHII VQVNPPTIKF VTEMNELEFS
     NSNKVIFYDV KNMRFNLSAK NLQQALSMCA VIKTSCSLRT VAAKDCKLIL TSKSTLLTVE
     AFLTQEQLKE ESRFERMGKQ DDGKGDRSHK NDDGSALASK QEMQYKITNY MVPAKNGTAG
     SSLFNEKEDS ESDDSMHFDY SSNPNPKRQR CVV