ID   VPB11_MYCTU             Reviewed;          72 AA.
AC   P9WLU3; L0T9T0; P64877; Q10771;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Antitoxin VapB11;
GN   Name=vapB11; OrderedLocusNames=Rv1560; ORFNames=MTCY48.05c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   EXPRESSION IN E.COLI, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19016878; DOI=10.1111/j.1574-6968.2008.01400.x;
RA   Gupta A.;
RT   "Killing activity and rescue function of genome-wide toxin-antitoxin loci
RT   of Mycobacterium tuberculosis.";
RL   FEMS Microbiol. Lett. 290:45-53(2009).
RN   [4]
RP   EXPRESSION IN M.SMEGMATIS, FUNCTION AS AN ANTITOXIN, AND INDUCTION DURING
RP   MACROPHAGE INFECTION.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in E.coli and M.smegmatis neutralizes the effect of
CC       cognate toxin VapC11. {ECO:0000269|PubMed:19016878,
CC       ECO:0000269|PubMed:20011113, ECO:0000305|PubMed:15718296}.
CC   -!- INDUCTION: Induced during infection of mouse macrophages.
CC       {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP44324.1; -; Genomic_DNA.
DR   PIR; E70763; E70763.
DR   RefSeq; NP_216076.1; NC_000962.3.
DR   RefSeq; WP_003407785.1; NC_000962.3.
DR   PDB; 6A7V; X-ray; 1.67 A; D/H/K/U=7-68.
DR   PDBsum; 6A7V; -.
DR   AlphaFoldDB; P9WLU3; -.
DR   SMR; P9WLU3; -.
DR   STRING; 83332.Rv1560; -.
DR   PaxDb; P9WLU3; -.
DR   DNASU; 886359; -.
DR   GeneID; 886359; -.
DR   KEGG; mtu:Rv1560; -.
DR   TubercuList; Rv1560; -.
DR   eggNOG; COG5450; Bacteria.
DR   OMA; DEMRTDW; -.
DR   PhylomeDB; P9WLU3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0097351; F:toxin sequestering activity; IPI:MTBBASE.
DR   GO; GO:0098754; P:detoxification; IMP:UniProtKB.
DR   GO; GO:0045727; P:positive regulation of translation; IMP:MTBBASE.
DR   GO; GO:0075136; P:response to host; IEP:MTBBASE.
DR   InterPro; IPR019239; VapB_antitoxin.
DR   Pfam; PF09957; VapB_antitoxin; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..72
FT                   /note="Antitoxin VapB11"
FT                   /id="PRO_0000103881"
FT   STRAND          8..12
FT                   /evidence="ECO:0007829|PDB:6A7V"
FT   HELIX           15..25
FT                   /evidence="ECO:0007829|PDB:6A7V"
FT   HELIX           30..42
FT                   /evidence="ECO:0007829|PDB:6A7V"
FT   HELIX           48..53
FT                   /evidence="ECO:0007829|PDB:6A7V"
FT   TURN            54..56
FT                   /evidence="ECO:0007829|PDB:6A7V"
FT   HELIX           63..66
FT                   /evidence="ECO:0007829|PDB:6A7V"
SQ   SEQUENCE   72 AA;  8241 MW;  FCCF47E0223701B9 CRC64;
     MYRWCMSRTN IDIDDELAAE VMRRFGLTTK RAAVDLALRR LVGSPLSREF LLGLEGVGWE
     GDLDDLRSDR PD